EHD2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
EHD2		EH-domain containing 2		pdf			NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway.

Gene is only very lowly expressed throughout the human cells datasets. The bat cells homolog is more highly expressed, and upregulated in Ebola infected cells after 23 h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	5	4	5	7	6	6	8	7	8
Read_Max	R. aegyptiacus	Transcriptome	256	279	293	253	229	245	198	249	400
Read_Max	R. aegyptiacus	Genome	292	275	260	271	198	149	174	308	441
DESeq	H. sapiens	Genome	31.44	15.28	28.8	31.8	15.63	18.11	29.07	31.38	55.37
DESeq	R. aegyptiacus	Transcriptome	2538.22	2514.39	3817.08	2601.5	2500.0	2496.79	2311.47	2267.29	3800.73
DESeq	R. aegyptiacus	Genome	4000.46	3891.69	5511.94	4164.22	3775.88	3904.48	3770.56	3281.21	5436.82

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	31.44	31.8	29.07	0.02	-0.11	-0.13
7h	15.28	15.63	31.38	0.03	1.04	1.01
23h	28.8	18.11	55.37	-0.67	0.94	1.61

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	31.44	15.28	28.8	-1.04	-0.13	0.91
Ebov	31.8	15.63	18.11	-1.02	-0.81	0.21
Marv	29.07	31.38	55.37	0.11	0.93	0.82

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2538.22	2601.5	2311.47	0.04	-0.14	-0.17
7h	2514.39	2500.0	2267.29	-0.01	-0.15	-0.14
23h	3817.08	2496.79	3800.73	-0.61	-0.01	0.61

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2538.22	2514.39	3817.08	-0.01	0.59	0.6
Ebov	2601.5	2500.0	2496.79	-0.06	-0.06	-0.0
Marv	2311.47	2267.29	3800.73	-0.03	0.72	0.75

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material