ARHGDIA

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ARHGDIA	GDIA1, RHOGDI,RHOGDI	Rho GDP dissociation inhibitor (GDI) alpha	NM_004309	pdf			NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants.

Constant expression in human cells and bat cells mock probes but downregulation in bat cells Ebola virus infection probes and upregulation in bat cells Marburg virus infection probes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	224	286	198	233	275	192	295	397	246
Read_Max	R. aegyptiacus	Transcriptome	1245	1536	1148	1095	1009	1274	772	1401	1873
Read_Max	R. aegyptiacus	Genome	1225	1038	897	1341	800	692	607	1563	1898
DESeq	H. sapiens	Genome	1793.11	1978.53	1333.37	1912.78	1384.64	1368.24	2049.27	2215.2	1708.13
DESeq	R. aegyptiacus	Transcriptome	4036.19	5242.91	5098.47	4008.88	4458.02	4366.38	3278.15	4240.28	5558.9
DESeq	R. aegyptiacus	Genome	6503.0	5860.35	7058.41	8523.96	6481.39	6546.63	5813.83	5786.13	7938.61

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1793.11	1912.78	2049.27	0.09	0.19	0.1
7h	1978.53	1384.64	2215.2	-0.51	0.16	0.68
23h	1333.37	1368.24	1708.13	0.04	0.36	0.32

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1793.11	1978.53	1333.37	0.14	-0.43	-0.57
Ebov	1912.78	1384.64	1368.24	-0.47	-0.48	-0.02
Marv	2049.27	2215.2	1708.13	0.11	-0.26	-0.38

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	4036.19	4008.88	3278.15	-0.01	-0.3	-0.29
7h	5242.91	4458.02	4240.28	-0.23	-0.31	-0.07
23h	5098.47	4366.38	5558.9	-0.22	0.12	0.35

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	4036.19	5242.91	5098.47	0.38	0.34	-0.04
Ebov	4008.88	4458.02	4366.38	0.15	0.12	-0.03
Marv	3278.15	4240.28	5558.9	0.37	0.76	0.39

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material