RAN

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
RAN ARA24, Gsp1, TC4 RAN, member RAS oncogene family NM_006325 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.

Very high expression in both human cells and bat cells but downregulation after 23 h of Ebola infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome1170 1198 1484 1282 2082 983 1712 1819 1543
Read_Max
batR. aegyptiacusTranscriptome 2843 2913 1275 2317 1977 1627 2254 2816 2050
Read_Max
bat_genomeR. aegyptiacusGenome 4101 3065 1519 3801 2185 1270 2496 4162 3083
DESeq
humanH. sapiensGenome 4778.62 4840.3 5208.37 5598.33 5849.37 3090.79 5679.15 5233.55 5868.32
DESeq
batR. aegyptiacusTranscriptome 7531.18 8061.29 5548.0 7457.29 7602.02 5771.47 9290.7 7823.54 6152.83
DESeq
bat_genomeR. aegyptiacusGenome 12845.3 12254.62 8778.94 14648.33 12972.82 10073.85 15597.26 12685.55 10685.27

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4778.62 5598.33 5679.15 0.23 0.25 0.02
7h 4840.3 5849.37 5233.55 0.27 0.11 -0.16
23h 5208.37 3090.79 5868.32 -0.75 0.17 0.92

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4778.62 4840.3 5208.37 0.02 0.12 0.11
Ebov 5598.33 5849.37 3090.79 0.06 -0.86 -0.92
Marv 5679.15 5233.55 5868.32 -0.12 0.05 0.17

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 7531.18 7457.29 9290.7 -0.01 0.3 0.32
7h 8061.29 7602.02 7823.54 -0.08 -0.04 0.04
23h 5548.0 5771.47 6152.83 0.06 0.15 0.09

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 7531.18 8061.29 5548.0 0.1 -0.44 -0.54
Ebov 7457.29 7602.02 5771.47 0.03 -0.37 -0.4
Marv 9290.7 7823.54 6152.83 -0.25 -0.59 -0.35