GRB2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
GRB2	GRB2, ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2,NCKAP2	growth factor receptor-bound protein 2		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences.

Expression of this gene is slightly upregulated 7 h after infection with Ebola, but returns to the starting level 23 h after infection in human cells. In contrast, the expression level after Ebola infection is constant in bat cells, while it increases 23 h after Marburg virus infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	443	423	477	489	616	525	519	604	513
Read_Max	R. aegyptiacus	Transcriptome	268	262	173	184	179	266	211	235	358
Read_Max	R. aegyptiacus	Genome	272	249	197	248	191	207	191	401	411
DESeq	H. sapiens	Genome	5509.26	4627.14	5634.29	5811.64	5447.77	5979.23	5309.84	4767.53	6051.0
DESeq	R. aegyptiacus	Transcriptome	1015.05	1216.4	1067.4	956.04	960.3	1285.46	1136.77	1004.84	1396.16
DESeq	R. aegyptiacus	Genome	1967.14	1808.94	1943.68	2250.48	1817.07	2435.89	2206.33	1934.0	2271.48

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	5509.26	5811.64	5309.84	0.08	-0.05	-0.13
7h	4627.14	5447.77	4767.53	0.24	0.04	-0.19
23h	5634.29	5979.23	6051.0	0.09	0.1	0.02

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	5509.26	4627.14	5634.29	-0.25	0.03	0.28
Ebov	5811.64	5447.77	5979.23	-0.09	0.04	0.13
Marv	5309.84	4767.53	6051.0	-0.16	0.19	0.34

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1015.05	956.04	1136.77	-0.09	0.16	0.25
7h	1216.4	960.3	1004.84	-0.34	-0.28	0.07
23h	1067.4	1285.46	1396.16	0.27	0.39	0.12

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1015.05	1216.4	1067.4	0.26	0.07	-0.19
Ebov	956.04	960.3	1285.46	0.01	0.43	0.42
Marv	1136.77	1004.84	1396.16	-0.18	0.3	0.47

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material