DDX3X
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| DDX3X | DBX, HLP2, DDX14 | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | NM_024005 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome.
The expression of DDX3X is upregulated after 3 h of Ebola infection and equal after 3 h infection with Marburg virus in human cells. The helicase's expression decreases from 7 to 23 h after infection for both viruses in human cells.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 2411 | 2251 | 2233 | 2089 | 3166 | 2632 | 2934 | 2906 | 2291 |
Read_Max |  | R. aegyptiacus | Transcriptome | 1651 | 1498 | 840 | 1223 | 1085 | 1254 | 1392 | 1426 | 1080 |
Read_Max |  | R. aegyptiacus | Genome | 1903 | 1314 | 751 | 1532 | 926 | 768 | 1224 | 1802 | 1216 |
DESeq | | H. sapiens | Genome | 39658.87 | 32346.27 | 34389.47 | 35956.47 | 35235.1 | 35705.92 | 37340.98 | 32301.95 | 38540.92 |
DESeq | | R. aegyptiacus | Transcriptome | 13927.17 | 13737.07 | 10730.98 | 12065.85 | 12191.54 | 14231.48 | 16179.83 | 11955.41 | 10669.82 |
DESeq | | R. aegyptiacus | Genome | 20642.55 | 17951.6 | 14579.87 | 21841.16 | 18686.31 | 21785.99 | 25134.42 | 17616.09 | 16082.7 |