Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

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EP300

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
EP300	KAT3B, p300,p300, KAT3B	E1A binding protein p300	NM_001429	pdf

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Description

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

The EP300 gene is highly expressed in all investigated cells of human and bats, however, 3X up-regulated in EBOV-infected human cells at 23 h p.i.. We were able to observe a miRNA in the 5'UTR and pseudogenes (RP11-12M9.3 and RP11-12M9.4) upstream of this gene being expressed (see Fig.~ reffig:ep300). Also a Y-RNA, which is, e.g., necessary for DNA-replication trough the interaction with the chromatin and initiation proteins, at position 41,461,558-41,461,650 of chromosome 22 is located in the 5'-upstream, but no expression is detected.

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