FBLN5
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| FBLN5 | EVEC, UP50, DANCE, ARMD3 | fibulin 5 |  |
NONE |  |
 |
Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).
The gene is equally expressed in human cells possibly showing alternative isoform usage in the Ebola after 3 h (first exon of short isoform seems to be expressed here).
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 19 | 21 | 16 | 18 | 20 | 13 | 26 | 34 | 11 |
Read_Max |  | R. aegyptiacus | Transcriptome | 7 | 8 | 5 | 5 | 2 | 5 | 5 | 4 | 6 |
Read_Max |  | R. aegyptiacus | Genome | 7 | 5 | 4 | 7 | 2 | 2 | 4 | 4 | 12 |
DESeq | | H. sapiens | Genome | 168.44 | 231.49 | 175.74 | 209.75 | 164.4 | 70.74 | 247.49 | 220.82 | 146.7 |
DESeq | | R. aegyptiacus | Transcriptome | 17.8 | 22.78 | 26.65 | 14.74 | 13.05 | 16.4 | 14.35 | 14.22 | 23.74 |
DESeq | | R. aegyptiacus | Genome | 16.33 | 24.64 | 30.13 | 32.59 | 8.93 | 15.66 | 19.12 | 18.24 | 40.24 |