FBLN5

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
FBLN5 EVEC, UP50, DANCE, ARMD3 fibulin 5 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).

The gene is equally expressed in human cells possibly showing alternative isoform usage in the Ebola after 3 h (first exon of short isoform seems to be expressed here).

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome19 21 16 18 20 13 26 34 11
Read_Max
batR. aegyptiacusTranscriptome 7 8 5 5 2 5 5 4 6
Read_Max
bat_genomeR. aegyptiacusGenome 7 5 4 7 2 2 4 4 12
DESeq
humanH. sapiensGenome 168.44 231.49 175.74 209.75 164.4 70.74 247.49 220.82 146.7
DESeq
batR. aegyptiacusTranscriptome 17.8 22.78 26.65 14.74 13.05 16.4 14.35 14.22 23.74
DESeq
bat_genomeR. aegyptiacusGenome 16.33 24.64 30.13 32.59 8.93 15.66 19.12 18.24 40.24

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 168.44 209.75 247.49 0.32 0.56 0.24
7h 231.49 164.4 220.82 -0.49 -0.07 0.43
23h 175.74 70.74 146.7 -1.31 -0.26 1.05

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 168.44 231.49 175.74 0.46 0.06 -0.4
Ebov 209.75 164.4 70.74 -0.35 -1.57 -1.22
Marv 247.49 220.82 146.7 -0.16 -0.75 -0.59

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 17.8 14.74 14.35 -0.27 -0.31 -0.04
7h 22.78 13.05 14.22 -0.8 -0.68 0.12
23h 26.65 16.4 23.74 -0.7 -0.17 0.53

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 17.8 22.78 26.65 0.36 0.58 0.23
Ebov 14.74 13.05 16.4 -0.18 0.15 0.33
Marv 14.35 14.22 23.74 -0.01 0.73 0.74