BRAF

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
BRAF BRAF1 B-Raf proto-oncogene, serine/threonine kinase NM_004333 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.

This gene shows an increase in expression over the time points in the human cells Ebola data. Especially at 23 h the expression is strong (twice as high as in the 7 h time point).

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome131 121 135 119 187 517 126 169 86
Read_Max
batR. aegyptiacusTranscriptome 117 106 65 95 76 124 66 98 76
Read_Max
bat_genomeR. aegyptiacusGenome 143 104 65 108 69 71 58 115 88
DESeq
humanH. sapiensGenome 1734.26 1432.9 1353.23 1581.99 1513.9 4456.71 1444.0 1275.16 1063.34
DESeq
batR. aegyptiacusTranscriptome 1141.91 973.14 843.86 897.44 896.78 1332.94 880.91 862.74 731.38
DESeq
bat_genomeR. aegyptiacusGenome 2462.15 2129.29 1843.26 2112.23 1999.0 3062.49 2136.61 1933.2 1739.78

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1734.26 1581.99 1444.0 -0.13 -0.26 -0.13
7h 1432.9 1513.9 1275.16 0.08 -0.17 -0.25
23h 1353.23 4456.71 1063.34 1.72 -0.35 -2.07

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1734.26 1432.9 1353.23 -0.28 -0.36 -0.08
Ebov 1581.99 1513.9 4456.71 -0.06 1.49 1.56
Marv 1444.0 1275.16 1063.34 -0.18 -0.44 -0.26

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1141.91 897.44 880.91 -0.35 -0.37 -0.03
7h 973.14 896.78 862.74 -0.12 -0.17 -0.06
23h 843.86 1332.94 731.38 0.66 -0.21 -0.87

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1141.91 973.14 843.86 -0.23 -0.44 -0.21
Ebov 897.44 896.78 1332.94 -0.0 0.57 0.57
Marv 880.91 862.74 731.38 -0.03 -0.27 -0.24