Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material

Back to supplement page

BRAF

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
BRAF	BRAF1	B-Raf proto-oncogene, serine/threonine kinase	NM_004333	pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.

This gene shows an increase in expression over the time points in the human cells Ebola data. Especially at 23 h the expression is strong (twice as high as in the 7 h time point).

Show legend