CREBBP

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CREBBP CREBBP, CBP, KAT3A, RSTS,RTS CREB binding protein NM_004380 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

It is constantly expressed in both human cells and bat cells under all investigated conditions.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome277 169 154 164 242 370 192 190 105
Read_Max
batR. aegyptiacusTranscriptome 210 186 98 141 132 243 138 140 142
Read_Max
bat_genomeR. aegyptiacusGenome 221 130 67 179 77 112 104 145 124
DESeq
humanH. sapiensGenome 7846.32 5406.33 3939.54 5525.33 4964.06 10165.18 5362.48 4692.39 3844.77
DESeq
batR. aegyptiacusTranscriptome 5107.37 4456.85 3363.89 3920.06 3799.87 6216.73 4337.16 3206.69 3401.87
DESeq
bat_genomeR. aegyptiacusGenome 5258.61 3648.0 3294.89 4866.32 3658.69 6106.71 4439.65 3135.31 3280.93

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 7846.32 5525.33 5362.48 -0.51 -0.55 -0.04
7h 5406.33 4964.06 4692.39 -0.12 -0.2 -0.08
23h 3939.54 10165.18 3844.77 1.37 -0.04 -1.4

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 7846.32 5406.33 3939.54 -0.54 -0.99 -0.46
Ebov 5525.33 4964.06 10165.18 -0.15 0.88 1.03
Marv 5362.48 4692.39 3844.77 -0.19 -0.48 -0.29

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 5107.37 3920.06 4337.16 -0.38 -0.24 0.15
7h 4456.85 3799.87 3206.69 -0.23 -0.47 -0.24
23h 3363.89 6216.73 3401.87 0.89 0.02 -0.87

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 5107.37 4456.85 3363.89 -0.2 -0.6 -0.41
Ebov 3920.06 3799.87 6216.73 -0.04 0.67 0.71
Marv 4337.16 3206.69 3401.87 -0.44 -0.35 0.09