EGFR

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
EGFR EGFR, ERBB, ERBB1, HER1, PIG61, mENA,ERBB1 epidermal growth factor receptor NM_005228 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

EGFR seems downregulated in human cells infected with Ebola and Marburg at late stage in the infection. In bat cells cell culture this gene seems not to be modulated.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome378 452 281 365 458 214 405 497 224
Read_Max
batR. aegyptiacusTranscriptome 166 135 143 105 111 180 118 122 159
Read_Max
bat_genomeR. aegyptiacusGenome 183 112 122 122 89 104 99 140 174
DESeq
humanH. sapiensGenome 11207.29 11969.21 8624.67 9894.14 10433.6 6612.19 9746.75 10209.5 7422.14
DESeq
batR. aegyptiacusTranscriptome 2484.46 2314.7 2775.11 2053.01 2161.61 3638.82 2136.82 1857.49 2655.74
DESeq
bat_genomeR. aegyptiacusGenome 4559.06 3769.39 4756.56 4357.76 3854.01 6776.38 4427.28 3398.57 4999.3

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 11207.29 9894.14 9746.75 -0.18 -0.2 -0.02
7h 11969.21 10433.6 10209.5 -0.2 -0.23 -0.03
23h 8624.67 6612.19 7422.14 -0.38 -0.22 0.17

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 11207.29 11969.21 8624.67 0.09 -0.38 -0.47
Ebov 9894.14 10433.6 6612.19 0.08 -0.58 -0.66
Marv 9746.75 10209.5 7422.14 0.07 -0.39 -0.46

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2484.46 2053.01 2136.82 -0.28 -0.22 0.06
7h 2314.7 2161.61 1857.49 -0.1 -0.32 -0.22
23h 2775.11 3638.82 2655.74 0.39 -0.06 -0.45

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2484.46 2314.7 2775.11 -0.1 0.16 0.26
Ebov 2053.01 2161.61 3638.82 0.07 0.83 0.75
Marv 2136.82 1857.49 2655.74 -0.2 0.31 0.52