EGFR

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
EGFR	EGFR, ERBB, ERBB1, HER1, PIG61, mENA,ERBB1	epidermal growth factor receptor	NM_005228	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

EGFR seems downregulated in human cells infected with Ebola and Marburg at late stage in the infection. In bat cells cell culture this gene seems not to be modulated.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	378	452	281	365	458	214	405	497	224
Read_Max	R. aegyptiacus	Transcriptome	166	135	143	105	111	180	118	122	159
Read_Max	R. aegyptiacus	Genome	183	112	122	122	89	104	99	140	174
DESeq	H. sapiens	Genome	11207.29	11969.21	8624.67	9894.14	10433.6	6612.19	9746.75	10209.5	7422.14
DESeq	R. aegyptiacus	Transcriptome	2484.46	2314.7	2775.11	2053.01	2161.61	3638.82	2136.82	1857.49	2655.74
DESeq	R. aegyptiacus	Genome	4559.06	3769.39	4756.56	4357.76	3854.01	6776.38	4427.28	3398.57	4999.3

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	11207.29	9894.14	9746.75	-0.18	-0.2	-0.02
7h	11969.21	10433.6	10209.5	-0.2	-0.23	-0.03
23h	8624.67	6612.19	7422.14	-0.38	-0.22	0.17

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	11207.29	11969.21	8624.67	0.09	-0.38	-0.47
Ebov	9894.14	10433.6	6612.19	0.08	-0.58	-0.66
Marv	9746.75	10209.5	7422.14	0.07	-0.39	-0.46

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2484.46	2053.01	2136.82	-0.28	-0.22	0.06
7h	2314.7	2161.61	1857.49	-0.1	-0.32	-0.22
23h	2775.11	3638.82	2655.74	0.39	-0.06	-0.45

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2484.46	2314.7	2775.11	-0.1	0.16	0.26
Ebov	2053.01	2161.61	3638.82	0.07	0.83	0.75
Marv	2136.82	1857.49	2655.74	-0.2	0.31	0.52

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material