DAG1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
DAG1 156DAG, A3a, AGRNR, DAG,A3a, 156DAG dystroglycan 1 (dystrophin-associated glycoprotein 1) pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein. In the bat transcripts the exon at location 49,547,853-49,548,253 on chromosome 3 (hg19) is missing.

The DAG1 is strongly down-regulated in Ebola infected human cells cells, which is not observable in bat cells cell lines. Further is DAG1 known to be associated with the Lassa-Fever\footnote{\url{http://biograph.be/concept/graph/C0023092/C1413902 }. }%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%

\igvfigure{ \beginfigure[H] \centering \caption\igv of gene DAG1. % <- say something about the figure here \endfigure }

\sashimifigure{ \beginfigure[H] \centering \includegraphics[width=\textwidth]../../input/holy_folders/hg19.goi.00532/snapshots//hg19.goi.00532_sashimi.eps % \caption\sashimi of gene DAG1. % <- say something about the figure here \endfigure }

\ucscfigure{ \beginfigure[H] \centering \includegraphics[width=\textwidth]../../input/holy_folders/hg19.goi.00532/snapshots//hg19.goi.00532_ucsc.eps % \caption\ucsc of gene DAG1. % <- say something about the figure here \endfigure }

\beginfigure[H] \centering \includegraphics[width=\textwidth]../../input/holy_folders/hg19.goi.00532/snapshots//rae.goi.00532_igv.eps % \captionExpression pattern of the DAG1 gene in bats. Note the missing strong down-regulation in ebola infected cells. % <- say something about the figure here \endfigure

\setcounterfigure0\enddocument

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome533 403 334 479 561 158 634 486 314
Read_Max
batR. aegyptiacusTranscriptome 492 468 295 355 290 348 278 375 450
Read_Max
bat_genomeR. aegyptiacusGenome 527 364 254 427 241 199 234 448 499
DESeq
humanH. sapiensGenome 14971.14 11235.92 7938.63 13662.96 10965.27 3101.31 13897.68 10204.71 8221.34
DESeq
batR. aegyptiacusTranscriptome 5508.96 5702.2 5144.89 4971.25 4573.0 4232.93 4747.64 4723.61 5218.64
DESeq
bat_genomeR. aegyptiacusGenome 4712.9 4285.97 4286.82 5309.7 4158.71 3861.4 4225.99 3939.36 4365.72

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 14971.14 13662.96 13897.68 -0.13 -0.11 0.02
7h 11235.92 10965.27 10204.71 -0.04 -0.14 -0.1
23h 7938.63 3101.31 8221.34 -1.36 0.05 1.41

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 14971.14 11235.92 7938.63 -0.41 -0.92 -0.5
Ebov 13662.96 10965.27 3101.31 -0.32 -2.14 -1.82
Marv 13897.68 10204.71 8221.34 -0.45 -0.76 -0.31

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 5508.96 4971.25 4747.64 -0.15 -0.21 -0.07
7h 5702.2 4573.0 4723.61 -0.32 -0.27 0.05
23h 5144.89 4232.93 5218.64 -0.28 0.02 0.3

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 5508.96 5702.2 5144.89 0.05 -0.1 -0.15
Ebov 4971.25 4573.0 4232.93 -0.12 -0.23 -0.11
Marv 4747.64 4723.61 5218.64 -0.01 0.14 0.14