DAG1
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| DAG1 | 156DAG, A3a, AGRNR, DAG,A3a, 156DAG | dystroglycan 1 (dystrophin-associated glycoprotein 1) |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein. In the bat transcripts the exon at location 49,547,853-49,548,253 on chromosome 3 (hg19) is missing.
The DAG1 is strongly down-regulated in Ebola infected human cells cells, which is not observable in bat cells cell lines. Further is DAG1 known to be associated with the Lassa-Fever\footnote{\url{http://biograph.be/concept/graph/C0023092/C1413902 }. }%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
\igvfigure{ \beginfigure[H] \centering \caption\igv of gene DAG1. % <- say something about the figure here \endfigure }
\sashimifigure{ \beginfigure[H] \centering \includegraphics[width=\textwidth]../../input/holy_folders/hg19.goi.00532/snapshots//hg19.goi.00532_sashimi.eps % \caption\sashimi of gene DAG1. % <- say something about the figure here \endfigure }
\ucscfigure{ \beginfigure[H] \centering \includegraphics[width=\textwidth]../../input/holy_folders/hg19.goi.00532/snapshots//hg19.goi.00532_ucsc.eps % \caption\ucsc of gene DAG1. % <- say something about the figure here \endfigure }
\beginfigure[H] \centering \includegraphics[width=\textwidth]../../input/holy_folders/hg19.goi.00532/snapshots//rae.goi.00532_igv.eps % \captionExpression pattern of the DAG1 gene in bats. Note the missing strong down-regulation in ebola infected cells. % <- say something about the figure here \endfigure
\setcounterfigure0\enddocument
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 533 | 403 | 334 | 479 | 561 | 158 | 634 | 486 | 314 |
Read_Max |  | R. aegyptiacus | Transcriptome | 492 | 468 | 295 | 355 | 290 | 348 | 278 | 375 | 450 |
Read_Max |  | R. aegyptiacus | Genome | 527 | 364 | 254 | 427 | 241 | 199 | 234 | 448 | 499 |
DESeq | | H. sapiens | Genome | 14971.14 | 11235.92 | 7938.63 | 13662.96 | 10965.27 | 3101.31 | 13897.68 | 10204.71 | 8221.34 |
DESeq | | R. aegyptiacus | Transcriptome | 5508.96 | 5702.2 | 5144.89 | 4971.25 | 4573.0 | 4232.93 | 4747.64 | 4723.61 | 5218.64 |
DESeq | | R. aegyptiacus | Genome | 4712.9 | 4285.97 | 4286.82 | 5309.7 | 4158.71 | 3861.4 | 4225.99 | 3939.36 | 4365.72 |