TNFSF10

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TNFSF10 TL2, APO2L, CD253,,TRAIL, Apo-2L, TL2, CD253 tumor necrosis factor (ligand) superfamily, member 10 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.

The expression of this gene is very low in all human cells probes, and in 23 h after Ebola infection there is no expression. This gene was found to be not expressed in bat cells.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome8 8 7 6 10 3 4 8 6
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 0 0 0 0 0 0 0 0 0
DESeq
humanH. sapiensGenome 32.46 60.15 42.7 55.75 43.27 10.21 35.21 42.57 34.71
DESeq
batR. aegyptiacusTranscriptome 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0
DESeq
bat_genomeR. aegyptiacusGenome 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 32.46 55.75 35.21 0.78 0.12 -0.66
7h 60.15 43.27 42.57 -0.48 -0.5 -0.02
23h 42.7 10.21 34.71 -2.06 -0.3 1.77

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 32.46 60.15 42.7 0.89 0.4 -0.49
Ebov 55.75 43.27 10.21 -0.37 -2.45 -2.08
Marv 35.21 42.57 34.71 0.27 -0.02 -0.29

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 1.0 1.0 0.0 0.0 0.0
7h 1.0 1.0 1.0 0.0 0.0 0.0
23h 1.0 1.0 1.0 0.0 0.0 0.0

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 1.0 1.0 0.0 0.0 0.0
Ebov 1.0 1.0 1.0 0.0 0.0 0.0
Marv 1.0 1.0 1.0 0.0 0.0 0.0