TNFRSF4

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TNFRSF4 OX40, ACT35,ACT35, OX40, CD134 tumor necrosis factor receptor superfamily, member 4 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the TNF-receptorsuperfamily. This receptor has been shown to activate NF-kappaB through itsinteraction with adaptor proteins TRAF2 and TRAF5. Knockout studies in micesuggested that this receptor promotes the expression of apoptosis inhibitorsBCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockoutstudies also suggested the roles of this receptor in CD4+ T cell response,as well as in T cell-dependent B cell proliferation and differentiation.

This gene was found to be no expressed in all probes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome0 0 0 0 2 0 0 2 2
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 2 0 2 0 2 0 0 3 0
DESeq
humanH. sapiensGenome 1.0 1.0 1.0 1.0 2.63 1.0 1.0 2.6 3.17
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 1.72 0.0 4.46 0.0 2.23 0.0 0.0 1.59 0.0

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 1.0 1.0 0.0 0.0 0.0
7h 1.0 2.63 2.6 1.4 1.38 -0.02
23h 1.0 1.0 3.17 0.0 1.66 1.66

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 1.0 1.0 0.0 0.0 0.0
Ebov 1.0 2.63 1.0 1.4 0.0 -1.4
Marv 1.0 2.6 3.17 1.38 1.66 0.29

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA