CASP3

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
CASP3	CPP32, SCA-1, CPP32B,CPP32, CPP32B, Yama, apopain	caspase 3, apoptosis-related cysteine peptidase	NM_004346	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.

The expression level of this gene was found to be a only slightly changed among different samples.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	225	144	97	179	138	213	243	187	68
Read_Max	R. aegyptiacus	Transcriptome	719	706	514	595	551	572	443	669	615
Read_Max	R. aegyptiacus	Genome	738	581	428	585	451	309	374	787	610
DESeq	H. sapiens	Genome	1295.87	999.46	913.41	1243.2	1116.37	1498.52	1287.86	955.42	771.93
DESeq	R. aegyptiacus	Transcriptome	2554.19	2581.56	2510.04	2674.75	2739.82	2329.97	2365.98	2988.57	2201.77
DESeq	R. aegyptiacus	Genome	2573.01	2637.66	2315.24	2687.93	2805.96	2345.82	2411.0	2935.49	2128.49

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1295.87	1243.2	1287.86	-0.06	-0.01	0.05
7h	999.46	1116.37	955.42	0.16	-0.07	-0.22
23h	913.41	1498.52	771.93	0.71	-0.24	-0.96

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1295.87	999.46	913.41	-0.37	-0.5	-0.13
Ebov	1243.2	1116.37	1498.52	-0.16	0.27	0.42
Marv	1287.86	955.42	771.93	-0.43	-0.74	-0.31

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2554.19	2674.75	2365.98	0.07	-0.11	-0.18
7h	2581.56	2739.82	2988.57	0.09	0.21	0.13
23h	2510.04	2329.97	2201.77	-0.11	-0.19	-0.08

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2554.19	2581.56	2510.04	0.02	-0.03	-0.04
Ebov	2674.75	2739.82	2329.97	0.03	-0.2	-0.23
Marv	2365.98	2988.57	2201.77	0.34	-0.1	-0.44

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material