CASP3

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CASP3 CPP32, SCA-1, CPP32B,CPP32, CPP32B, Yama, apopain caspase 3, apoptosis-related cysteine peptidase NM_004346 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.

The expression level of this gene was found to be a only slightly changed among different samples.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome225 144 97 179 138 213 243 187 68
Read_Max
batR. aegyptiacusTranscriptome 719 706 514 595 551 572 443 669 615
Read_Max
bat_genomeR. aegyptiacusGenome 738 581 428 585 451 309 374 787 610
DESeq
humanH. sapiensGenome 1295.87 999.46 913.41 1243.2 1116.37 1498.52 1287.86 955.42 771.93
DESeq
batR. aegyptiacusTranscriptome 2554.19 2581.56 2510.04 2674.75 2739.82 2329.97 2365.98 2988.57 2201.77
DESeq
bat_genomeR. aegyptiacusGenome 2573.01 2637.66 2315.24 2687.93 2805.96 2345.82 2411.0 2935.49 2128.49

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1295.87 1243.2 1287.86 -0.06 -0.01 0.05
7h 999.46 1116.37 955.42 0.16 -0.07 -0.22
23h 913.41 1498.52 771.93 0.71 -0.24 -0.96

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1295.87 999.46 913.41 -0.37 -0.5 -0.13
Ebov 1243.2 1116.37 1498.52 -0.16 0.27 0.42
Marv 1287.86 955.42 771.93 -0.43 -0.74 -0.31

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2554.19 2674.75 2365.98 0.07 -0.11 -0.18
7h 2581.56 2739.82 2988.57 0.09 0.21 0.13
23h 2510.04 2329.97 2201.77 -0.11 -0.19 -0.08

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2554.19 2581.56 2510.04 0.02 -0.03 -0.04
Ebov 2674.75 2739.82 2329.97 0.03 -0.2 -0.23
Marv 2365.98 2988.57 2201.77 0.34 -0.1 -0.44