IQGAP1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
IQGAP1	SAR1, p195, HUMORFA01,p195, KIAA0051, SAR1	IQ motif containing GTPase activating protein 1	NM_003870	pdf		NONE

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Description

This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. IQGAP1 is well-expressed in human and so is its homolog in bat with approx.~a 2-fold enrichment in comparison to human. In human, there is some evidence of a slight up-regulation subsequent to Ebola and Marburg infection, both after 7h and 23h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	286	302	224	237	307	452	264	326	443
Read_Max	R. aegyptiacus	Transcriptome	789	641	414	589	492	778	574	635	812
Read_Max	R. aegyptiacus	Genome	894	598	366	631	415	465	486	750	931
DESeq	H. sapiens	Genome	7594.65	7516.44	8149.11	7422.28	7569.57	12943.09	7114.25	6852.23	15502.22
DESeq	R. aegyptiacus	Transcriptome	16122.46	13473.84	13381.71	14650.78	14792.38	21241.51	16472.4	13664.84	18286.79
DESeq	R. aegyptiacus	Genome	19803.78	17640.37	15411.12	17281.95	18883.87	26928.0	20923.04	16278.39	22529.83

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	7594.65	7422.28	7114.25	-0.03	-0.09	-0.06
7h	7516.44	7569.57	6852.23	0.01	-0.13	-0.14
23h	8149.11	12943.09	15502.22	0.67	0.93	0.26

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	7594.65	7516.44	8149.11	-0.01	0.1	0.12
Ebov	7422.28	7569.57	12943.09	0.03	0.8	0.77
Marv	7114.25	6852.23	15502.22	-0.05	1.12	1.18

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	16122.46	14650.78	16472.4	-0.14	0.03	0.17
7h	13473.84	14792.38	13664.84	0.13	0.02	-0.11
23h	13381.71	21241.51	18286.79	0.67	0.45	-0.22

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	16122.46	13473.84	13381.71	-0.26	-0.27	-0.01
Ebov	14650.78	14792.38	21241.51	0.01	0.54	0.52
Marv	16472.4	13664.84	18286.79	-0.27	0.15	0.42

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material