CASP6

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CASP6 MCH2, caspase6 caspase 6, apoptosis-related cysteine peptidase NM_001226 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade.

This gene was found to be with 1/5 down-regulation in 23h-Ebola-human probe, but not in bat.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome92 161 131 93 152 37 158 216 104
Read_Max
batR. aegyptiacusTranscriptome 212 180 250 227 165 173 149 241 245
Read_Max
bat_genomeR. aegyptiacusGenome 296 290 251 211 159 132 157 381 352
DESeq
humanH. sapiensGenome 531.73 603.74 769.45 516.59 661.93 158.91 587.85 621.3 737.13
DESeq
batR. aegyptiacusTranscriptome 743.68 675.41 1011.21 861.73 810.27 672.1 718.5 849.52 771.62
DESeq
bat_genomeR. aegyptiacusGenome 1122.36 1403.71 1559.86 1090.18 1270.16 1091.32 1168.39 1590.65 1293.71

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 531.73 516.59 587.85 -0.04 0.14 0.19
7h 603.74 661.93 621.3 0.13 0.04 -0.09
23h 769.45 158.91 737.13 -2.28 -0.06 2.21

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 531.73 603.74 769.45 0.18 0.53 0.35
Ebov 516.59 661.93 158.91 0.36 -1.7 -2.06
Marv 587.85 621.3 737.13 0.08 0.33 0.25

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 743.68 861.73 718.5 0.21 -0.05 -0.26
7h 675.41 810.27 849.52 0.26 0.33 0.07
23h 1011.21 672.1 771.62 -0.59 -0.39 0.2

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 743.68 675.41 1011.21 -0.14 0.44 0.58
Ebov 861.73 810.27 672.1 -0.09 -0.36 -0.27
Marv 718.5 849.52 771.62 0.24 0.1 -0.14