MAP2K1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MAP2K1 MAPKK1, MEK1, PRKMK1,MEK1, MAPKK1 mitogen-activated protein kinase kinase 1 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

It is constantly expressed in human cells and bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome203 283 254 285 308 276 311 362 253
Read_Max
batR. aegyptiacusTranscriptome 759 683 461 609 564 733 613 642 722
Read_Max
bat_genomeR. aegyptiacusGenome 798 623 390 633 458 435 527 791 811
DESeq
humanH. sapiensGenome 2171.63 2611.87 2497.95 2559.55 2475.62 2426.24 2489.63 2468.59 2556.27
DESeq
batR. aegyptiacusTranscriptome 4369.73 4278.03 3605.75 3713.12 4162.34 5177.35 4759.87 3950.28 4138.37
DESeq
bat_genomeR. aegyptiacusGenome 6079.33 5274.41 4997.57 6246.82 5731.35 7117.1 6531.28 5594.23 5708.23

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2171.63 2559.55 2489.63 0.24 0.2 -0.04
7h 2611.87 2475.62 2468.59 -0.08 -0.08 -0.0
23h 2497.95 2426.24 2556.27 -0.04 0.03 0.08

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2171.63 2611.87 2497.95 0.27 0.2 -0.06
Ebov 2559.55 2475.62 2426.24 -0.05 -0.08 -0.03
Marv 2489.63 2468.59 2556.27 -0.01 0.04 0.05

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4369.73 3713.12 4759.87 -0.23 0.12 0.36
7h 4278.03 4162.34 3950.28 -0.04 -0.11 -0.08
23h 3605.75 5177.35 4138.37 0.52 0.2 -0.32

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4369.73 4278.03 3605.75 -0.03 -0.28 -0.25
Ebov 3713.12 4162.34 5177.35 0.16 0.48 0.31
Marv 4759.87 3950.28 4138.37 -0.27 -0.2 0.07