MKNK1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MKNK1 MNK1 MAP kinase interacting serine/threonine kinase 1 NM_003684 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a Ser/Thr protein kinase that interacts with, and isactivated by ERK1 and p38 mitogen-activated protein kinases, and thus mayplay a role in the response to environmental stress and cytokines. Thiskinase may also regulate transcription by phosphorylating eIF4E viainteraction with the C-terminal region of eIF4G. Alternatively splicedtranscript variants have been noted for this gene.

It is constantly expressed in human cells and bat cells at low level.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome36 55 43 46 68 70 57 75 76
Read_Max
batR. aegyptiacusTranscriptome 49 42 62 46 36 60 47 62 72
Read_Max
bat_genomeR. aegyptiacusGenome 70 75 64 78 48 51 52 112 96
DESeq
humanH. sapiensGenome 357.19 566.01 542.09 452.71 527.79 597.11 509.78 598.11 560.98
DESeq
batR. aegyptiacusTranscriptome 204.31 208.86 247.75 213.44 210.16 283.3 245.73 258.78 247.67
DESeq
bat_genomeR. aegyptiacusGenome 645.4 843.32 753.15 682.35 841.56 758.44 752.31 849.25 701.22

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 357.19 452.71 509.78 0.34 0.51 0.17
7h 566.01 527.79 598.11 -0.1 0.08 0.18
23h 542.09 597.11 560.98 0.14 0.05 -0.09

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 357.19 566.01 542.09 0.66 0.6 -0.06
Ebov 452.71 527.79 597.11 0.22 0.4 0.18
Marv 509.78 598.11 560.98 0.23 0.14 -0.09

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 204.31 213.44 245.73 0.06 0.27 0.2
7h 208.86 210.16 258.78 0.01 0.31 0.3
23h 247.75 283.3 247.67 0.19 -0.0 -0.19

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 204.31 208.86 247.75 0.03 0.28 0.25
Ebov 213.44 210.16 283.3 -0.02 0.41 0.43
Marv 245.73 258.78 247.67 0.07 0.01 -0.06