TGFB1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TGFB1 A8K792, NM_000660, NP_000651, P01137, Q9UCG4, TGFB, TGFB1_HUMAN,CED, TGFbeta transforming growth factor, beta 1 pdf NONE

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Description

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.

The gene is not differentially expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome68 41 52 52 39 65 73 84 64
Read_Max
batR. aegyptiacusTranscriptome 79 69 27 31 28 20 53 40 39
Read_Max
bat_genomeR. aegyptiacusGenome 107 45 23 95 28 12 54 67 47
DESeq
humanH. sapiensGenome 489.11 365.09 337.57 459.55 286.35 494.47 415.92 491.0 582.73
DESeq
batR. aegyptiacusTranscriptome 354.7 373.15 139.03 157.58 149.93 93.39 318.04 166.24 138.33
DESeq
bat_genomeR. aegyptiacusGenome 918.69 488.29 282.29 969.71 479.94 237.58 870.39 470.22 373.3

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 489.11 459.55 415.92 -0.09 -0.23 -0.14
7h 365.09 286.35 491.0 -0.35 0.43 0.78
23h 337.57 494.47 582.73 0.55 0.79 0.24

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 489.11 365.09 337.57 -0.42 -0.53 -0.11
Ebov 459.55 286.35 494.47 -0.68 0.11 0.79
Marv 415.92 491.0 582.73 0.24 0.49 0.25

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 354.7 157.58 318.04 -1.17 -0.16 1.01
7h 373.15 149.93 166.24 -1.32 -1.17 0.15
23h 139.03 93.39 138.33 -0.57 -0.01 0.57

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 354.7 373.15 139.03 0.07 -1.35 -1.42
Ebov 157.58 149.93 93.39 -0.07 -0.75 -0.68
Marv 318.04 166.24 138.33 -0.94 -1.2 -0.27