Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material

CASP8

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
CASP8	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5,MCH5	caspase 8, apoptosis-related cysteine peptidase	NM_001228	pdf

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Description

Homo sapiens caspase 8, apoptosis-related cysteine peptidase (CASP8) encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Based on the y-max values no clear expression pattern could be observed, although the \textttDESeq normalized read counts show a slightly downregulation in all human EBOV samples and an upregulation in human MARV samples. A partial homologous sequence of the P.~vampyrus ortholog could be blasted in the bat transcriptome.

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Read_Max

R. aegyptiacusGenome 257 302 196 189 188 152 147 436 343

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source		Species	Mapping on	Mock3h	Mock7h	Mock23h	EBOV3h	EBOV7h	EBOV23h	MARV3h	MARV7h	MARV23h
Read_Max		H. sapiens	Genome	148	96	78	94	106	78	88	169	127
Read_Max		R. aegyptiacus	Transcriptome	169	164	189	247	159	252	165	259	296
DESeq		H. sapiens	Genome	1267.45	1227.91	1226.15	1000.24	1186.28	808.98	906.28	1277.56	1613.54
DESeq		R. aegyptiacus	Transcriptome	1056.22	980.4	1306.82	1421.2	1270.21	1531.84	1113.41	1546.84	1414.53
DESeq		R. aegyptiacus	Genome	1907.85	2471.55	2373.26	1818.94	2372.9	2668.26	1911.7	2616.72	2582.27

Human Condition Comparisons

	Mock	EBOV	MARV	FCMock_EBOV	FCMock_MARV	FCEBOV_MARV
3h	1267.45	1000.24	906.28	-0.34	-0.48	-0.14
7h	1227.91	1186.28	1277.56	-0.05	0.06	0.11
23h	1226.15	808.98	1613.54	-0.6	0.4	1.0

Human Time Point Comparisons

	3h	7h	23h	FC3h_7h	FC3h_23h	FC7h_23h
Mock	1267.45	1227.91	1226.15	-0.05	-0.05	-0.0
Ebov	1000.24	1186.28	808.98	0.25	-0.31	-0.55
Marv	906.28	1277.56	1613.54	0.5	0.83	0.34

Bat Condition Comparisons

	Mock	EBOV	MARV	FCMock_EBOV	FCMock_MARV	FCEBOV_MARV
3h	1056.22	1421.2	1113.41	0.43	0.08	-0.35
7h	980.4	1270.21	1546.84	0.37	0.66	0.28
23h	1306.82	1531.84	1414.53	0.23	0.11	-0.11

Bat Time Point Comparisons

	3h	7h	23h	FC3h_7h	FC3h_23h	FC7h_23h
Mock	1056.22	980.4	1306.82	-0.11	0.31	0.41
Ebov	1421.2	1270.21	1531.84	-0.16	0.11	0.27
Marv	1113.41	1546.84	1414.53	0.47	0.35	-0.13