CASP8

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CASP8 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5,MCH5 caspase 8, apoptosis-related cysteine peptidase NM_001228 pdf

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Description

Homo sapiens caspase 8, apoptosis-related cysteine peptidase (CASP8) encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Based on the y-max values no clear expression pattern could be observed, although the \textttDESeq normalized read counts show a slightly downregulation in all human EBOV samples and an upregulation in human MARV samples. A partial homologous sequence of the P.~vampyrus ortholog could be blasted in the bat transcriptome.

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Read_Max
bat_genomeR. aegyptiacusGenome 257 302 196 189 188 152 147 436 343

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome148 96 78 94 106 78 88 169 127
Read_Max
batR. aegyptiacusTranscriptome 169 164 189 247 159 252 165 259 296
DESeq
humanH. sapiensGenome 1267.45 1227.91 1226.15 1000.24 1186.28 808.98 906.28 1277.56 1613.54
DESeq
batR. aegyptiacusTranscriptome 1056.22 980.4 1306.82 1421.2 1270.21 1531.84 1113.41 1546.84 1414.53
DESeq
bat_genomeR. aegyptiacusGenome 1907.85 2471.55 2373.26 1818.94 2372.9 2668.26 1911.7 2616.72 2582.27

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1267.45 1000.24 906.28 -0.34 -0.48 -0.14
7h 1227.91 1186.28 1277.56 -0.05 0.06 0.11
23h 1226.15 808.98 1613.54 -0.6 0.4 1.0

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1267.45 1227.91 1226.15 -0.05 -0.05 -0.0
Ebov 1000.24 1186.28 808.98 0.25 -0.31 -0.55
Marv 906.28 1277.56 1613.54 0.5 0.83 0.34

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1056.22 1421.2 1113.41 0.43 0.08 -0.35
7h 980.4 1270.21 1546.84 0.37 0.66 0.28
23h 1306.82 1531.84 1414.53 0.23 0.11 -0.11

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1056.22 980.4 1306.82 -0.11 0.31 0.41
Ebov 1421.2 1270.21 1531.84 -0.16 0.11 0.27
Marv 1113.41 1546.84 1414.53 0.47 0.35 -0.13