CAPN1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
CAPN1	CANP, CANPL1, muCANP, muCL,muCANP, CANP	calpain 1, (mu/I) large subunit		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene.

It is constantly expressed in human cells and bat cells.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	74	100	113	76	130	141	115	130	128
Read_Max	R. aegyptiacus	Transcriptome	127	138	203	144	122	158	92	168	238
Read_Max	R. aegyptiacus	Genome	127	150	153	137	107	91	76	197	245
DESeq	H. sapiens	Genome	1062.47	1173.85	1035.52	1047.01	900.94	1393.25	1104.52	1171.25	1517.85
DESeq	R. aegyptiacus	Transcriptome	1300.7	1631.21	2447.74	1623.56	1611.88	1906.52	1175.7	1659.2	2386.33
DESeq	R. aegyptiacus	Genome	1710.19	1932.15	2793.91	2219.86	2025.78	2442.42	1540.61	1958.58	2789.47

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1062.47	1047.01	1104.52	-0.02	0.06	0.08
7h	1173.85	900.94	1171.25	-0.38	-0.0	0.38
23h	1035.52	1393.25	1517.85	0.43	0.55	0.12

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1062.47	1173.85	1035.52	0.14	-0.04	-0.18
Ebov	1047.01	900.94	1393.25	-0.22	0.41	0.63
Marv	1104.52	1171.25	1517.85	0.08	0.46	0.37

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1300.7	1623.56	1175.7	0.32	-0.15	-0.47
7h	1631.21	1611.88	1659.2	-0.02	0.02	0.04
23h	2447.74	1906.52	2386.33	-0.36	-0.04	0.32

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1300.7	1631.21	2447.74	0.33	0.91	0.59
Ebov	1623.56	1611.88	1906.52	-0.01	0.23	0.24
Marv	1175.7	1659.2	2386.33	0.5	1.02	0.52

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material