PTEN
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| PTEN | BZS, MHAM, MMAC1, PTEN1, TEP1,MMAC1 | phosphatase and tensin homolog | NM_000314 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
This gene is not conspicuous.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 158 | 154 | 178 | 138 | 176 | 158 | 158 | 143 | 147 |
Read_Max |  | R. aegyptiacus | Transcriptome | 879 | 635 | 532 | 682 | 537 | 557 | 630 | 757 | 582 |
Read_Max |  | R. aegyptiacus | Genome | 926 | 683 | 443 | 588 | 452 | 323 | 540 | 924 | 634 |
DESeq | | H. sapiens | Genome | 2686.13 | 2132.53 | 2720.35 | 2278.94 | 2384.57 | 2180.17 | 2169.45 | 1730.0 | 2811.79 |
DESeq | | R. aegyptiacus | Transcriptome | 3776.59 | 3099.85 | 3575.22 | 3592.25 | 3440.68 | 3320.59 | 4217.02 | 3595.01 | 2948.77 |
DESeq | | R. aegyptiacus | Genome | 10107.29 | 9665.33 | 10150.23 | 9154.96 | 10038.51 | 9846.71 | 12171.94 | 9708.83 | 8855.59 |