TNFRSF19

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TNFRSF19 TNFRSF19, TAJ, TAJ-alpha, TRADE, TROY,TAJ-alpha tumor necrosis factor receptor superfamily, member 19 NM_018647 pdf

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Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.

TNFRSF19 shows no modulation in its expression due to Ebola virus or Marburg virus infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome28 26 11 27 31 57 45 31 21
Read_Max
batR. aegyptiacusTranscriptome 27 21 23 17 11 24 20 16 18
Read_Max
bat_genomeR. aegyptiacusGenome 40 18 18 21 14 5 18 20 15
DESeq
humanH. sapiensGenome 374.44 357.96 140.0 403.66 318.05 806.34 449.25 275.18 156.49
DESeq
batR. aegyptiacusTranscriptome 92.58 82.69 69.41 101.72 74.37 36.93 105.57 74.53 55.23
DESeq
bat_genomeR. aegyptiacusGenome 323.99 264.68 190.8 311.06 276.8 83.55 363.22 233.92 148.12

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 374.44 403.66 449.25 0.11 0.26 0.15
7h 357.96 318.05 275.18 -0.17 -0.38 -0.21
23h 140.0 806.34 156.49 2.53 0.16 -2.37

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 374.44 357.96 140.0 -0.06 -1.42 -1.35
Ebov 403.66 318.05 806.34 -0.34 1.0 1.34
Marv 449.25 275.18 156.49 -0.71 -1.52 -0.81

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 92.58 101.72 105.57 0.14 0.19 0.05
7h 82.69 74.37 74.53 -0.15 -0.15 0.0
23h 69.41 36.93 55.23 -0.91 -0.33 0.58

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 92.58 82.69 69.41 -0.16 -0.42 -0.25
Ebov 101.72 74.37 36.93 -0.45 -1.46 -1.01
Marv 105.57 74.53 55.23 -0.5 -0.93 -0.43