IRAK3

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
IRAK3	B4DQ57, IRAK3_HUMAN, NM_007199, NP_009130, Q9Y616,IRAK-M	interleukin-1 receptor-associated kinase 3		pdf		NONE

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Description

Homo sapiens interleukin-1 receptor-associated kinase 3 (IRAK3), transcript variant 1 gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. IRAK3 inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.

In bat cells a homolog with rarely mapped reads was found. Other homolog fragments are located at a human cells intron locus, which is not conserved between Human, Rhesus, Mouse, Dog, Elephant, but therefore in Chicken, *tropicalis, Zebrafish and Lamprey. The transcripts observed, are upregulated in MOCK, 2 fold upregulated during Ebola infection and 2 fold downregulated with slight upregulation to the 23 h sample during Marburg infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	98	109	136	130	131	351	187	110	159
Read_Max	R. aegyptiacus	Transcriptome	7	4	4	10	3	6	5	5	6
Read_Max	R. aegyptiacus	Genome	156	129	85	121	77	49	83	164	154
DESeq	H. sapiens	Genome	610.89	533.37	695.98	687.69	565.19	1373.51	659.78	524.57	898.06
DESeq	R. aegyptiacus	Transcriptome	16.96	13.71	16.88	19.31	14.14	22.81	16.57	17.52	15.0
DESeq	R. aegyptiacus	Genome	996.03	1139.03	964.03	958.85	937.55	801.52	964.85	1034.0	940.1

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	610.89	687.69	659.78	0.17	0.11	-0.06
7h	533.37	565.19	524.57	0.08	-0.02	-0.11
23h	695.98	1373.51	898.06	0.98	0.37	-0.61

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	610.89	533.37	695.98	-0.2	0.19	0.38
Ebov	687.69	565.19	1373.51	-0.28	1.0	1.28
Marv	659.78	524.57	898.06	-0.33	0.44	0.78

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	16.96	19.31	16.57	0.19	-0.03	-0.22
7h	13.71	14.14	17.52	0.04	0.35	0.31
23h	16.88	22.81	15.0	0.43	-0.17	-0.6

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	16.96	13.71	16.88	-0.31	-0.01	0.3
Ebov	19.31	14.14	22.81	-0.45	0.24	0.69
Marv	16.57	17.52	15.0	0.08	-0.14	-0.22

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material