IRAK3

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
IRAK3 B4DQ57, IRAK3_HUMAN, NM_007199, NP_009130, Q9Y616,IRAK-M interleukin-1 receptor-associated kinase 3 pdf NONE

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Description

Homo sapiens interleukin-1 receptor-associated kinase 3 (IRAK3), transcript variant 1 gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. IRAK3 inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.

In bat cells a homolog with rarely mapped reads was found. Other homolog fragments are located at a human cells intron locus, which is not conserved between Human, Rhesus, Mouse, Dog, Elephant, but therefore in Chicken, *tropicalis, Zebrafish and Lamprey. The transcripts observed, are upregulated in MOCK, 2 fold upregulated during Ebola infection and 2 fold downregulated with slight upregulation to the 23 h sample during Marburg infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome98 109 136 130 131 351 187 110 159
Read_Max
batR. aegyptiacusTranscriptome 7 4 4 10 3 6 5 5 6
Read_Max
bat_genomeR. aegyptiacusGenome 156 129 85 121 77 49 83 164 154
DESeq
humanH. sapiensGenome 610.89 533.37 695.98 687.69 565.19 1373.51 659.78 524.57 898.06
DESeq
batR. aegyptiacusTranscriptome 16.96 13.71 16.88 19.31 14.14 22.81 16.57 17.52 15.0
DESeq
bat_genomeR. aegyptiacusGenome 996.03 1139.03 964.03 958.85 937.55 801.52 964.85 1034.0 940.1

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 610.89 687.69 659.78 0.17 0.11 -0.06
7h 533.37 565.19 524.57 0.08 -0.02 -0.11
23h 695.98 1373.51 898.06 0.98 0.37 -0.61

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 610.89 533.37 695.98 -0.2 0.19 0.38
Ebov 687.69 565.19 1373.51 -0.28 1.0 1.28
Marv 659.78 524.57 898.06 -0.33 0.44 0.78

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 16.96 19.31 16.57 0.19 -0.03 -0.22
7h 13.71 14.14 17.52 0.04 0.35 0.31
23h 16.88 22.81 15.0 0.43 -0.17 -0.6

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 16.96 13.71 16.88 -0.31 -0.01 0.3
Ebov 19.31 14.14 22.81 -0.45 0.24 0.69
Marv 16.57 17.52 15.0 0.08 -0.14 -0.22