ARRB1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ARRB1	ARR2	arrestin, beta 1	NM_004041	pdf			NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.

The gene is expressed at a similar, moderate level in all human cells samples and about 15-fold less in all bat cells samples.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	124	153	100	117	144	97	112	181	82
Read_Max	R. aegyptiacus	Transcriptome	3	6	2	1	2	4	4	5	5
Read_Max	R. aegyptiacus	Genome	3	2	2	6	3	2	4	4	2
DESeq	H. sapiens	Genome	1577.98	1799.04	1398.9	1416.59	1373.26	1903.82	1337.86	1631.67	1259.06
DESeq	R. aegyptiacus	Transcriptome	9.4	17.34	4.66	3.75	5.38	11.27	14.35	9.26	9.75
DESeq	R. aegyptiacus	Genome	18.91	11.86	15.62	20.74	12.28	18.28	26.99	16.65	6.85

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1577.98	1416.59	1337.86	-0.16	-0.24	-0.08
7h	1799.04	1373.26	1631.67	-0.39	-0.14	0.25
23h	1398.9	1903.82	1259.06	0.44	-0.15	-0.6

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1577.98	1799.04	1398.9	0.19	-0.17	-0.36
Ebov	1416.59	1373.26	1903.82	-0.04	0.43	0.47
Marv	1337.86	1631.67	1259.06	0.29	-0.09	-0.37

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	9.4	3.75	14.35	-1.33	0.61	1.94
7h	17.34	5.38	9.26	-1.69	-0.91	0.78
23h	4.66	11.27	9.75	1.27	1.07	-0.21

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	9.4	17.34	4.66	0.88	-1.01	-1.9
Ebov	3.75	5.38	11.27	0.52	1.59	1.07
Marv	14.35	9.26	9.75	-0.63	-0.56	0.07

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material