Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

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TP53

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
TP53	P53, BCC7, LFS1, TRP53,p53, LFS1	tumor protein p53	NM_000546	pdf

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Description

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277)

This gene is strongly expressed in human cells and bat cells samples. In human cells MOCK and Marburg the expression level decreases. During Ebola infection this gene is upregulated. In contrast, the TP53 transcription increases in bat cells samples during Marburg infection and is downregulated in MOCK and Ebola samples.

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