TP53

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TP53 P53, BCC7, LFS1, TRP53,p53, LFS1 tumor protein p53 NM_000546 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277)

This gene is strongly expressed in human cells and bat cells samples. In human cells MOCK and Marburg the expression level decreases. During Ebola infection this gene is upregulated. In contrast, the TP53 transcription increases in bat cells samples during Marburg infection and is downregulated in MOCK and Ebola samples.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome236 237 189 192 325 294 236 262 172
Read_Max
batR. aegyptiacusTranscriptome 400 389 303 352 297 384 260 417 463
Read_Max
bat_genomeR. aegyptiacusGenome 801 585 371 791 352 272 311 663 594
DESeq
humanH. sapiensGenome 2987.52 2790.35 2465.19 2357.65 2829.26 3210.53 2573.84 2718.79 2531.26
DESeq
batR. aegyptiacusTranscriptome 2214.77 2281.12 1878.5 1966.02 1877.98 2043.83 1761.94 1807.92 2035.57
DESeq
bat_genomeR. aegyptiacusGenome 5890.26 5174.01 4912.77 6524.3 4785.98 5259.5 4757.9 4657.76 5019.0

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2987.52 2357.65 2573.84 -0.34 -0.22 0.13
7h 2790.35 2829.26 2718.79 0.02 -0.04 -0.06
23h 2465.19 3210.53 2531.26 0.38 0.04 -0.34

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2987.52 2790.35 2465.19 -0.1 -0.28 -0.18
Ebov 2357.65 2829.26 3210.53 0.26 0.45 0.18
Marv 2573.84 2718.79 2531.26 0.08 -0.02 -0.1

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2214.77 1966.02 1761.94 -0.17 -0.33 -0.16
7h 2281.12 1877.98 1807.92 -0.28 -0.34 -0.05
23h 1878.5 2043.83 2035.57 0.12 0.12 -0.01

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2214.77 2281.12 1878.5 0.04 -0.24 -0.28
Ebov 1966.02 1877.98 2043.83 -0.07 0.06 0.12
Marv 1761.94 1807.92 2035.57 0.04 0.21 0.17