NRAS

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
NRAS N-ras neuroblastoma RAS viral (v-ras) oncogene homolog NM_002524 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This is an N-ras oncogene encoding a membrane protein that shuttles betweenthe Golgi apparatus and the plasma membrane. This shuttling is regulatedthrough palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex.The encoded protein, which has intrinsic GTPase activity, is activated by aguanine nucleotide-exchange factor and inactivated by a GTPase activatingprotein. Mutations in this gene have been associated with somatic rectalcancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome,Noonan syndrome, and juvenile myelomonocytic leukemia.

It is expressed constantly in human cells as well as in bat cells but at a distincthigher level. %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%

\igvfigure{\beginfigure[H]\centering\includegraphics[width=\textwidth]../../input/holy_folders/hg19.goi.00621/snapshots//hg19.goi.00621_igv.eps %\caption\igv of gene NRAS. % <- say something about the figure here\endfigure}

\sashimifigure{\beginfigure[H]\centering\includegraphics[width=\textwidth]../../input/holy_folders/hg19.goi.00621/snapshots//hg19.goi.00621_sashimi.eps %\caption\sashimi of gene NRAS. % <- say something about the figure here\endfigure}

\ucscfigure{\beginfigure[H]\centering\includegraphics[width=\textwidth]../../input/holy_folders/hg19.goi.00621/snapshots//hg19.goi.00621_ucsc.eps %\caption\ucsc of gene NRAS. % <- say something about the figure here\endfigure}

\setcounterfigure0\enddocument

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome649 646 635 606 772 440 731 734 667
Read_Max
batR. aegyptiacusTranscriptome 682 581 367 567 454 453 456 604 510
Read_Max
bat_genomeR. aegyptiacusGenome 761 574 348 580 400 286 420 762 628
DESeq
humanH. sapiensGenome 10785.14 9184.96 10721.52 9832.55 10141.75 6959.6 9803.76 8165.57 12867.58
DESeq
batR. aegyptiacusTranscriptome 1751.85 1587.64 1449.74 1692.24 1661.16 1409.93 1725.23 1659.2 1494.13
DESeq
bat_genomeR. aegyptiacusGenome 8506.24 8584.71 7230.24 7830.74 8641.11 8440.78 9549.53 8807.25 7867.55

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 10785.14 9832.55 9803.76 -0.13 -0.14 -0.0
7h 9184.96 10141.75 8165.57 0.14 -0.17 -0.31
23h 10721.52 6959.6 12867.58 -0.62 0.26 0.89

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 10785.14 9184.96 10721.52 -0.23 -0.01 0.22
Ebov 9832.55 10141.75 6959.6 0.04 -0.5 -0.54
Marv 9803.76 8165.57 12867.58 -0.26 0.39 0.66

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1751.85 1692.24 1725.23 -0.05 -0.02 0.03
7h 1587.64 1661.16 1659.2 0.07 0.06 -0.0
23h 1449.74 1409.93 1494.13 -0.04 0.04 0.08

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1751.85 1587.64 1449.74 -0.14 -0.27 -0.13
Ebov 1692.24 1661.16 1409.93 -0.03 -0.26 -0.24
Marv 1725.23 1659.2 1494.13 -0.06 -0.21 -0.15