WASL

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
WASL N-WASP, NWASP Wiskott-Aldrich syndrome-like NM_003941 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension.

It is upregulated in human cells after 23 h of Ebola infection and transcribed constantly in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome355 352 341 329 427 728 481 330 312
Read_Max
batR. aegyptiacusTranscriptome 309 259 242 292 234 359 268 358 268
Read_Max
bat_genomeR. aegyptiacusGenome 340 294 195 251 196 198 227 425 297
DESeq
humanH. sapiensGenome 5334.72 4231.43 4915.48 5083.88 4835.62 9213.77 4899.31 3655.63 5040.85
DESeq
batR. aegyptiacusTranscriptome 2252.58 2028.78 2447.74 2241.64 2255.79 2885.59 2371.54 2213.59 2027.7
DESeq
bat_genomeR. aegyptiacusGenome 3480.53 3613.32 3526.97 3203.4 3715.61 4694.25 3862.77 3636.45 3256.1

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 5334.72 5083.88 4899.31 -0.07 -0.12 -0.05
7h 4231.43 4835.62 3655.63 0.19 -0.21 -0.4
23h 4915.48 9213.77 5040.85 0.91 0.04 -0.87

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 5334.72 4231.43 4915.48 -0.33 -0.12 0.22
Ebov 5083.88 4835.62 9213.77 -0.07 0.86 0.93
Marv 4899.31 3655.63 5040.85 -0.42 0.04 0.46

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2252.58 2241.64 2371.54 -0.01 0.07 0.08
7h 2028.78 2255.79 2213.59 0.15 0.13 -0.03
23h 2447.74 2885.59 2027.7 0.24 -0.27 -0.51

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2252.58 2028.78 2447.74 -0.15 0.12 0.27
Ebov 2241.64 2255.79 2885.59 0.01 0.36 0.36
Marv 2371.54 2213.59 2027.7 -0.1 -0.23 -0.13