TNF

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TNF TNF, DIF, TNF-alpha, TNFA, TNFSF2,TNFSF2 tumor necrosis factor pdf NONE NONE NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

Not expressed in the examined transcriptome samples.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome0 0 0 0 0 3 0 2 0
Read_Max
batR. aegyptiacusTranscriptome 7 3 10 2 5 16 3 11 15
Read_Max
bat_genomeR. aegyptiacusGenome 8 4 9 4 4 8 3 9 16
DESeq
humanH. sapiensGenome 1.0 1.0 1.0 1.0 1.0 3.63 1.0 2.6 1.0
DESeq
batR. aegyptiacusTranscriptome 10.24 5.54 30.32 6.49 21.81 60.03 12.12 20.0 37.74
DESeq
bat_genomeR. aegyptiacusGenome 18.91 17.34 68.06 10.86 34.6 116.18 26.99 28.55 68.5

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 1.0 1.0 0.0 0.0 0.0
7h 1.0 1.0 2.6 0.0 1.38 1.38
23h 1.0 3.63 1.0 1.86 0.0 -1.86

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 1.0 1.0 0.0 0.0 0.0
Ebov 1.0 1.0 3.63 0.0 1.86 1.86
Marv 1.0 2.6 1.0 1.38 0.0 -1.38

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 10.24 6.49 12.12 -0.66 0.24 0.9
7h 5.54 21.81 20.0 1.98 1.85 -0.12
23h 30.32 60.03 37.74 0.99 0.32 -0.67

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 10.24 5.54 30.32 -0.89 1.57 2.45
Ebov 6.49 21.81 60.03 1.75 3.21 1.46
Marv 12.12 20.0 37.74 0.72 1.64 0.92