CSF1R

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CSF1R CD115 Antige, C-FMS, FIM2, CD115, HDLS,C-FMS, CSFR colony stimulating factor 1 receptor NM_005211 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants.

The gene CSF1R is not expressed in human cells or bat cells datasets, but it seems there is an unannotated pseudogene which is well expressed and conserved among many vertebrates.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome1832 1630 1948 1614 2191 2336 2109 1997 1796
Read_Max
batR. aegyptiacusTranscriptome NA 2 NA 2 NA NA 2 2 NA
Read_Max
bat_genomeR. aegyptiacusGenome 2 2 2 3 2 0 2 3 2
DESeq
humanH. sapiensGenome 1457.22 1310.52 1658.02 1392.63 1523.66 1730.12 1413.3 1268.77 1806.0
DESeq
batR. aegyptiacusTranscriptome 1.0 2.82 1.0 2.83 1.0 1.0 4.34 2.65 1.0
DESeq
bat_genomeR. aegyptiacusGenome 5.16 10.95 3.35 7.9 2.23 0.0 7.87 3.96 2.57

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1457.22 1392.63 1413.3 -0.07 -0.04 0.02
7h 1310.52 1523.66 1268.77 0.22 -0.05 -0.26
23h 1658.02 1730.12 1806.0 0.06 0.12 0.06

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1457.22 1310.52 1658.02 -0.15 0.19 0.34
Ebov 1392.63 1523.66 1730.12 0.13 0.31 0.18
Marv 1413.3 1268.77 1806.0 -0.16 0.35 0.51

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 2.83 4.34 1.5 2.12 0.62
7h 2.82 1.0 2.65 -1.5 -0.09 1.41
23h 1.0 1.0 1.0 0.0 0.0 0.0

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 2.82 1.0 1.5 0.0 -1.5
Ebov 2.83 1.0 1.0 -1.5 -1.5 0.0
Marv 4.34 2.65 1.0 -0.71 -2.12 -1.41