MAP3K7

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MAP3K7 TAK1, MEKK7, TGF1a,MEKK7 mitogen-activated protein kinase kinase kinase 7 NM_145331 pdf NONE NONE NONE

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Description

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

The gene MAP3K7 is moderately expressed in human cells and bat cells datasets. However it seems to be downregulated in bat cells over time, which can be seen by a 2-fold expression level decrease.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome284 281 290 227 425 273 259 411 320
Read_Max
batR. aegyptiacusTranscriptome 360 249 168 241 189 204 223 223 259
Read_Max
bat_genomeR. aegyptiacusGenome 408 275 168 266 187 127 196 333 312
DESeq
humanH. sapiensGenome 4284.42 4407.87 4513.39 3866.78 4575.47 3255.28 3904.56 4211.98 4663.54
DESeq
batR. aegyptiacusTranscriptome 2458.41 2160.39 1634.19 1839.66 1700.58 1915.51 2274.76 1812.88 1804.65
DESeq
bat_genomeR. aegyptiacusGenome 3933.43 3178.88 2641.05 3452.24 2961.1 3259.61 3994.34 3165.44 3112.26

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4284.42 3866.78 3904.56 -0.15 -0.13 0.01
7h 4407.87 4575.47 4211.98 0.05 -0.07 -0.12
23h 4513.39 3255.28 4663.54 -0.47 0.05 0.52

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4284.42 4407.87 4513.39 0.04 0.08 0.03
Ebov 3866.78 4575.47 3255.28 0.24 -0.25 -0.49
Marv 3904.56 4211.98 4663.54 0.11 0.26 0.15

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2458.41 1839.66 2274.76 -0.42 -0.11 0.31
7h 2160.39 1700.58 1812.88 -0.35 -0.25 0.09
23h 1634.19 1915.51 1804.65 0.23 0.14 -0.09

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2458.41 2160.39 1634.19 -0.19 -0.59 -0.4
Ebov 1839.66 1700.58 1915.51 -0.11 0.06 0.17
Marv 2274.76 1812.88 1804.65 -0.33 -0.33 -0.01