MAP3K7

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
MAP3K7	TAK1, MEKK7, TGF1a,MEKK7	mitogen-activated protein kinase kinase kinase 7	NM_145331	pdf		NONE	NONE	NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

The gene MAP3K7 is moderately expressed in human cells and bat cells datasets. However it seems to be downregulated in bat cells over time, which can be seen by a 2-fold expression level decrease.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	284	281	290	227	425	273	259	411	320
Read_Max	R. aegyptiacus	Transcriptome	360	249	168	241	189	204	223	223	259
Read_Max	R. aegyptiacus	Genome	408	275	168	266	187	127	196	333	312
DESeq	H. sapiens	Genome	4284.42	4407.87	4513.39	3866.78	4575.47	3255.28	3904.56	4211.98	4663.54
DESeq	R. aegyptiacus	Transcriptome	2458.41	2160.39	1634.19	1839.66	1700.58	1915.51	2274.76	1812.88	1804.65
DESeq	R. aegyptiacus	Genome	3933.43	3178.88	2641.05	3452.24	2961.1	3259.61	3994.34	3165.44	3112.26

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	4284.42	3866.78	3904.56	-0.15	-0.13	0.01
7h	4407.87	4575.47	4211.98	0.05	-0.07	-0.12
23h	4513.39	3255.28	4663.54	-0.47	0.05	0.52

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	4284.42	4407.87	4513.39	0.04	0.08	0.03
Ebov	3866.78	4575.47	3255.28	0.24	-0.25	-0.49
Marv	3904.56	4211.98	4663.54	0.11	0.26	0.15

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2458.41	1839.66	2274.76	-0.42	-0.11	0.31
7h	2160.39	1700.58	1812.88	-0.35	-0.25	0.09
23h	1634.19	1915.51	1804.65	0.23	0.14	-0.09

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2458.41	2160.39	1634.19	-0.19	-0.59	-0.4
Ebov	1839.66	1700.58	1915.51	-0.11	0.06	0.17
Marv	2274.76	1812.88	1804.65	-0.33	-0.33	-0.01

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material