PRKCA

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
PRKCA	PKCalpha, PKCA	protein kinase C, alpha		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. It is constantly expressed in human and bat. An putativ novel intronic transcription site could be observed in human.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	159	181	124	132	193	159	138	148	113
Read_Max	R. aegyptiacus	Transcriptome	185	150	121	140	108	150	114	144	178
Read_Max	R. aegyptiacus	Genome	197	139	88	134	88	87	99	164	187
DESeq	H. sapiens	Genome	4239.76	4326.28	4029.88	3605.56	4115.34	4292.22	3426.48	3628.45	4008.96
DESeq	R. aegyptiacus	Transcriptome	1891.32	1567.67	1552.35	1416.62	1470.61	1699.93	1497.19	1265.1	1574.6
DESeq	R. aegyptiacus	Genome	4791.96	3864.31	4032.42	4180.02	4379.71	4672.06	4402.54	3577.77	4107.15

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	4239.76	3605.56	3426.48	-0.23	-0.31	-0.07
7h	4326.28	4115.34	3628.45	-0.07	-0.25	-0.18
23h	4029.88	4292.22	4008.96	0.09	-0.01	-0.1

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	4239.76	4326.28	4029.88	0.03	-0.07	-0.1
Ebov	3605.56	4115.34	4292.22	0.19	0.25	0.06
Marv	3426.48	3628.45	4008.96	0.08	0.23	0.14

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1891.32	1416.62	1497.19	-0.42	-0.34	0.08
7h	1567.67	1470.61	1265.1	-0.09	-0.31	-0.22
23h	1552.35	1699.93	1574.6	0.13	0.02	-0.11

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1891.32	1567.67	1552.35	-0.27	-0.28	-0.01
Ebov	1416.62	1470.61	1699.93	0.05	0.26	0.21
Marv	1497.19	1265.1	1574.6	-0.24	0.07	0.32

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material