TNFSF9

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
TNFSF9	CD137L, 4-1BB-L,4-1BB-L	tumor necrosis factor (ligand) superfamily, member 9	NM_003811	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.

No significant different expression was observed in this gene in human cells probes, and no homolog was found in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	7	5	9	10	9	11	12	14	11
Read_Max	R. aegyptiacus	Transcriptome	2	1	6	NA	NA	4	1	2	7
Read_Max	R. aegyptiacus	Genome	2	3	5	1	0	2	2	3	8
DESeq	H. sapiens	Genome	38.55	28.54	37.73	43.21	51.4	43.11	54.51	58.55	91.25
DESeq	R. aegyptiacus	Transcriptome	2.68	3.72	13.22	1.0	1.0	4.85	3.22	2.65	12.37
DESeq	R. aegyptiacus	Genome	3.44	4.56	13.39	4.94	0.0	9.14	6.75	3.96	13.7

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	38.55	43.21	54.51	0.16	0.5	0.34
7h	28.54	51.4	58.55	0.85	1.04	0.19
23h	37.73	43.11	91.25	0.19	1.27	1.08

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	38.55	28.54	37.73	-0.43	-0.03	0.4
Ebov	43.21	51.4	43.11	0.25	-0.0	-0.25
Marv	54.51	58.55	91.25	0.1	0.74	0.64

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2.68	1.0	3.22	-1.42	0.26	1.69
7h	3.72	1.0	2.65	-1.9	-0.49	1.41
23h	13.22	4.85	12.37	-1.45	-0.1	1.35

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2.68	3.72	13.22	0.47	2.3	1.83
Ebov	1.0	1.0	4.85	0.0	2.28	2.28
Marv	3.22	2.65	12.37	-0.28	1.94	2.22

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material