ATF2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ATF2 NM_001256094, NR_045768, uc002ujp.3,TREB7, CRE-BP1, HB16 activating transcription factor 2 NM_001880 pdf

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Description

Homo sapiens activating transcription factor 2 (ATF2), transcript variant 7, non-coding RNA gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene.

The expression pattern are very diverse. For HG19 Mock nothing changes, whereas during ebola infection the expression is up- and durng marburg downregulated. In RAE MOCK the transcripts decrease, similar to ebola infected RAE samples. In contrast the marburg infected cells schow an upregulation and afterwards 2 fold downregulation after 7h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome336 337 338 265 414 439 343 367 280
Read_Max
batR. aegyptiacusTranscriptome 206 163 120 176 133 166 178 241 136
Read_Max
bat_genomeR. aegyptiacusGenome 284 205 110 185 128 116 168 304 202
DESeq
humanH. sapiensGenome 3402.57 3672.54 4145.05 3335.22 3647.9 4384.34 3262.45 3235.97 3871.95
DESeq
batR. aegyptiacusTranscriptome 1420.0 1276.3 1014.88 1296.67 1231.88 1207.19 1575.05 1241.14 937.81
DESeq
bat_genomeR. aegyptiacusGenome 2994.11 2808.33 2106.59 2749.15 2765.78 2734.83 3380.34 2762.62 2212.4

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3402.57 3335.22 3262.45 -0.03 -0.06 -0.03
7h 3672.54 3647.9 3235.97 -0.01 -0.18 -0.17
23h 4145.05 4384.34 3871.95 0.08 -0.1 -0.18

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3402.57 3672.54 4145.05 0.11 0.28 0.17
Ebov 3335.22 3647.9 4384.34 0.13 0.39 0.27
Marv 3262.45 3235.97 3871.95 -0.01 0.25 0.26

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1420.0 1296.67 1575.05 -0.13 0.15 0.28
7h 1276.3 1231.88 1241.14 -0.05 -0.04 0.01
23h 1014.88 1207.19 937.81 0.25 -0.11 -0.36

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1420.0 1276.3 1014.88 -0.15 -0.48 -0.33
Ebov 1296.67 1231.88 1207.19 -0.07 -0.1 -0.03
Marv 1575.05 1241.14 937.81 -0.34 -0.75 -0.4