CASP7

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CASP7 MCH3, CMH-1, LICE2, CASP-7, ICE-LAP3,MCH3, CMH-1, ICE-LAP3 caspase 7, apoptosis-related cysteine peptidase NM_033338 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

This gene is found to be expressed in all probes but without significant expressional levels.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome107 117 87 92 138 96 108 131 122
Read_Max
batR. aegyptiacusTranscriptome 164 159 109 187 143 196 141 194 204
Read_Max
bat_genomeR. aegyptiacusGenome 197 214 99 164 120 127 131 233 230
DESeq
humanH. sapiensGenome 898.07 994.36 934.26 988.83 984.67 789.24 992.24 945.03 1177.51
DESeq
batR. aegyptiacusTranscriptome 809.22 792.51 711.93 947.8 919.78 1033.96 1004.39 856.13 878.33
DESeq
bat_genomeR. aegyptiacusGenome 1474.71 1610.89 1284.26 1390.38 1712.15 1720.53 1729.53 1588.27 1656.73

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 898.07 988.83 992.24 0.14 0.14 0.0
7h 994.36 984.67 945.03 -0.01 -0.07 -0.06
23h 934.26 789.24 1177.51 -0.24 0.33 0.58

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 898.07 994.36 934.26 0.15 0.06 -0.09
Ebov 988.83 984.67 789.24 -0.01 -0.33 -0.32
Marv 992.24 945.03 1177.51 -0.07 0.25 0.32

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 809.22 947.8 1004.39 0.23 0.31 0.08
7h 792.51 919.78 856.13 0.21 0.11 -0.1
23h 711.93 1033.96 878.33 0.54 0.3 -0.24

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 809.22 792.51 711.93 -0.03 -0.18 -0.15
Ebov 947.8 919.78 1033.96 -0.04 0.13 0.17
Marv 1004.39 856.13 878.33 -0.23 -0.19 0.04