CASP10

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
CASP10	caspase10, MCH4, ALPS2, FLICE2,MCH4	caspase 10, apoptosis-related cysteine peptidase	NM_032977	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer.

This gene was found to be up-regulated expressed at Ebola-7 h in human cells, but no other special point was found.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	34	46	39	24	56	44	44	41	53
Read_Max	R. aegyptiacus	Transcriptome	423	340	264	350	299	538	289	434	367
Read_Max	R. aegyptiacus	Genome	493	370	230	319	260	299	261	544	416
DESeq	H. sapiens	Genome	872.7	907.67	991.84	561.08	962.72	711.6	675.57	799.55	1153.59
DESeq	R. aegyptiacus	Transcriptome	2618.88	2208.5	2265.73	2661.93	2665.35	3923.69	2717.5	2664.7	2244.63
DESeq	R. aegyptiacus	Genome	5708.07	5741.7	4747.63	4851.51	6109.72	8951.2	6093.84	5920.93	5010.43

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	872.7	561.08	675.57	-0.64	-0.37	0.27
7h	907.67	962.72	799.55	0.08	-0.18	-0.27
23h	991.84	711.6	1153.59	-0.48	0.22	0.7

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	872.7	907.67	991.84	0.06	0.18	0.13
Ebov	561.08	962.72	711.6	0.78	0.34	-0.44
Marv	675.57	799.55	1153.59	0.24	0.77	0.53

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2618.88	2661.93	2717.5	0.02	0.05	0.03
7h	2208.5	2665.35	2664.7	0.27	0.27	-0.0
23h	2265.73	3923.69	2244.63	0.79	-0.01	-0.81

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2618.88	2208.5	2265.73	-0.25	-0.21	0.04
Ebov	2661.93	2665.35	3923.69	0.0	0.56	0.56
Marv	2717.5	2664.7	2244.63	-0.03	-0.28	-0.25

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material