CASP10

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CASP10 caspase10, MCH4, ALPS2, FLICE2,MCH4 caspase 10, apoptosis-related cysteine peptidase NM_032977 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer.

This gene was found to be up-regulated expressed at Ebola-7 h in human cells, but no other special point was found.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome34 46 39 24 56 44 44 41 53
Read_Max
batR. aegyptiacusTranscriptome 423 340 264 350 299 538 289 434 367
Read_Max
bat_genomeR. aegyptiacusGenome 493 370 230 319 260 299 261 544 416
DESeq
humanH. sapiensGenome 872.7 907.67 991.84 561.08 962.72 711.6 675.57 799.55 1153.59
DESeq
batR. aegyptiacusTranscriptome 2618.88 2208.5 2265.73 2661.93 2665.35 3923.69 2717.5 2664.7 2244.63
DESeq
bat_genomeR. aegyptiacusGenome 5708.07 5741.7 4747.63 4851.51 6109.72 8951.2 6093.84 5920.93 5010.43

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 872.7 561.08 675.57 -0.64 -0.37 0.27
7h 907.67 962.72 799.55 0.08 -0.18 -0.27
23h 991.84 711.6 1153.59 -0.48 0.22 0.7

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 872.7 907.67 991.84 0.06 0.18 0.13
Ebov 561.08 962.72 711.6 0.78 0.34 -0.44
Marv 675.57 799.55 1153.59 0.24 0.77 0.53

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2618.88 2661.93 2717.5 0.02 0.05 0.03
7h 2208.5 2665.35 2664.7 0.27 0.27 -0.0
23h 2265.73 3923.69 2244.63 0.79 -0.01 -0.81

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2618.88 2208.5 2265.73 -0.25 -0.21 0.04
Ebov 2661.93 2665.35 3923.69 0.0 0.56 0.56
Marv 2717.5 2664.7 2244.63 -0.03 -0.28 -0.25