MYD88

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MYD88 myeloid differentiation primary response 88 NM_002468 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.

Constantly expressed in human cells and bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome61 59 39 49 71 62 56 78 55
Read_Max
batR. aegyptiacusTranscriptome 115 90 117 98 82 104 77 128 102
Read_Max
bat_genomeR. aegyptiacusGenome 127 101 97 88 72 62 68 158 113
DESeq
humanH. sapiensGenome 465.77 567.03 434.86 510.89 604.21 408.94 502.76 694.84 644.71
DESeq
batR. aegyptiacusTranscriptome 564.73 582.83 674.07 581.53 602.2 569.45 526.06 603.31 532.82
DESeq
bat_genomeR. aegyptiacusGenome 973.69 990.26 1132.51 1102.03 1048.05 1074.35 1021.08 958.67 936.67

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 465.77 510.89 502.76 0.13 0.11 -0.02
7h 567.03 604.21 694.84 0.09 0.29 0.2
23h 434.86 408.94 644.71 -0.09 0.57 0.66

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 465.77 567.03 434.86 0.28 -0.1 -0.38
Ebov 510.89 604.21 408.94 0.24 -0.32 -0.56
Marv 502.76 694.84 644.71 0.47 0.36 -0.11

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 564.73 581.53 526.06 0.04 -0.1 -0.14
7h 582.83 602.2 603.31 0.05 0.05 0.0
23h 674.07 569.45 532.82 -0.24 -0.34 -0.1

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 564.73 582.83 674.07 0.05 0.26 0.21
Ebov 581.53 602.2 569.45 0.05 -0.03 -0.08
Marv 526.06 603.31 532.82 0.2 0.02 -0.18