TAB1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
TAB1	MAP3K7IP1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	NM_153497	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

It is upregulated in human cells and bat cells after Ebola virus infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	47	77	60	58	84	156	81	102	49
Read_Max	R. aegyptiacus	Transcriptome	25	41	22	34	30	50	18	45	38
Read_Max	R. aegyptiacus	Genome	22	30	20	34	22	21	16	55	41
DESeq	H. sapiens	Genome	1081.75	1281.96	1150.69	1207.84	1176.53	2252.54	1173.82	1422.25	944.82
DESeq	R. aegyptiacus	Transcriptome	158.11	246.98	234.31	248.23	249.59	314.1	157.85	223.25	270.41
DESeq	R. aegyptiacus	Genome	267.27	370.55	371.55	357.47	319.21	366.82	307.0	318.76	382.72

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1081.75	1207.84	1173.82	0.16	0.12	-0.04
7h	1281.96	1176.53	1422.25	-0.12	0.15	0.27
23h	1150.69	2252.54	944.82	0.97	-0.28	-1.25

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1081.75	1281.96	1150.69	0.24	0.09	-0.16
Ebov	1207.84	1176.53	2252.54	-0.04	0.9	0.94
Marv	1173.82	1422.25	944.82	0.28	-0.31	-0.59

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	158.11	248.23	157.85	0.65	-0.0	-0.65
7h	246.98	249.59	223.25	0.02	-0.15	-0.16
23h	234.31	314.1	270.41	0.42	0.21	-0.22

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	158.11	246.98	234.31	0.64	0.57	-0.08
Ebov	248.23	249.59	314.1	0.01	0.34	0.33
Marv	157.85	223.25	270.41	0.5	0.78	0.28

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material