ITGB1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ITGB1	RP11-479G22.2, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB,CD29	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	NM_002211	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.

This gene was found with very expression level in both human and bats samples. 0.5 times down-regulation was found in Human-Ebola-23h sample.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	1865	1968	2367	2072	3733	1815	2535	2796	2222
Read_Max	R. aegyptiacus	Transcriptome	8969	7817	6048	8755	6988	6711	6960	9795	8106
Read_Max	R. aegyptiacus	Genome	9968	8747	4427	7493	5812	3322	5881	11563	7352
DESeq	H. sapiens	Genome	25566.53	27835.37	29019.28	29529.86	31493.09	20692.56	28777.7	26762.45	27494.57
DESeq	R. aegyptiacus	Transcriptome	101384.95	95119.63	91401.26	112188.68	112460.17	88874.16	114862.49	113187.43	89794.23
DESeq	R. aegyptiacus	Genome	108576.2	115143.41	88360.67	106641.31	118771.15	97786.95	126551.47	116659.8	94323.21

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	25566.53	29529.86	28777.7	0.21	0.17	-0.04
7h	27835.37	31493.09	26762.45	0.18	-0.06	-0.23
23h	29019.28	20692.56	27494.57	-0.49	-0.08	0.41

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	25566.53	27835.37	29019.28	0.12	0.18	0.06
Ebov	29529.86	31493.09	20692.56	0.09	-0.51	-0.61
Marv	28777.7	26762.45	27494.57	-0.1	-0.07	0.04

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	101384.95	112188.68	114862.49	0.15	0.18	0.03
7h	95119.63	112460.17	113187.43	0.24	0.25	0.01
23h	91401.26	88874.16	89794.23	-0.04	-0.03	0.01

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	101384.95	95119.63	91401.26	-0.09	-0.15	-0.06
Ebov	112188.68	112460.17	88874.16	0.0	-0.34	-0.34
Marv	114862.49	113187.43	89794.23	-0.02	-0.36	-0.33

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material