CASP9

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
CASP9	MCH6, APAF3, APAF-3,Caspase9,MCH6, ICE-LAP6, APAF-3, PPP1R56	caspase 9, apoptosis-related cysteine peptidase	NM_032996	pdf			NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the cysteine-aspartic acid protease (caspase)family. Sequential activation of caspases plays a central role in theexecution-phase of cell apoptosis. Caspases exist as inactive proenzymeswhich undergo proteolytic processing at conserved aspartic residues toproduce two subunits, large and small, that dimerize to form the activeenzyme. This protein can undergo autoproteolytic processing and activationby the apoptosome, a protein complex of cytochrome c and the apoptoticpeptidase activating factor 1; this step is thought to be one of theearliest in the caspase activation cascade. This protein is thought to playa central role in apoptosis and to be a tumor suppressor.

This gene seems to be expressed in all probes but without significantdifference.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	32	29	27	36	49	58	29	58	30
Read_Max	R. aegyptiacus	Transcriptome	21	27	21	23	19	29	17	25	34
Read_Max	R. aegyptiacus	Genome	29	23	14	24	16	12	12	37	35
DESeq	H. sapiens	Genome	332.84	342.66	257.15	377.43	305.86	398.41	301.0	346.32	268.49
DESeq	R. aegyptiacus	Transcriptome	48.05	71.8	64.52	61.43	61.23	54.89	55.51	59.66	77.97
DESeq	R. aegyptiacus	Genome	226.88	276.54	272.25	237.0	273.45	250.64	178.8	265.64	274.84

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	332.84	377.43	301.0	0.18	-0.15	-0.33
7h	342.66	305.86	346.32	-0.16	0.02	0.18
23h	257.15	398.41	268.49	0.63	0.06	-0.57

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	332.84	342.66	257.15	0.04	-0.37	-0.41
Ebov	377.43	305.86	398.41	-0.3	0.08	0.38
Marv	301.0	346.32	268.49	0.2	-0.16	-0.37

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	48.05	61.43	55.51	0.35	0.21	-0.15
7h	71.8	61.23	59.66	-0.23	-0.27	-0.04
23h	64.52	54.89	77.97	-0.23	0.27	0.51

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	48.05	71.8	64.52	0.58	0.43	-0.15
Ebov	61.43	61.23	54.89	-0.0	-0.16	-0.16
Marv	55.51	59.66	77.97	0.1	0.49	0.39

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material