CASP9

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CASP9 MCH6, APAF3, APAF-3,Caspase9,MCH6, ICE-LAP6, APAF-3, PPP1R56 caspase 9, apoptosis-related cysteine peptidase NM_032996 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the cysteine-aspartic acid protease (caspase)family. Sequential activation of caspases plays a central role in theexecution-phase of cell apoptosis. Caspases exist as inactive proenzymeswhich undergo proteolytic processing at conserved aspartic residues toproduce two subunits, large and small, that dimerize to form the activeenzyme. This protein can undergo autoproteolytic processing and activationby the apoptosome, a protein complex of cytochrome c and the apoptoticpeptidase activating factor 1; this step is thought to be one of theearliest in the caspase activation cascade. This protein is thought to playa central role in apoptosis and to be a tumor suppressor.

This gene seems to be expressed in all probes but without significantdifference.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome32 29 27 36 49 58 29 58 30
Read_Max
batR. aegyptiacusTranscriptome 21 27 21 23 19 29 17 25 34
Read_Max
bat_genomeR. aegyptiacusGenome 29 23 14 24 16 12 12 37 35
DESeq
humanH. sapiensGenome 332.84 342.66 257.15 377.43 305.86 398.41 301.0 346.32 268.49
DESeq
batR. aegyptiacusTranscriptome 48.05 71.8 64.52 61.43 61.23 54.89 55.51 59.66 77.97
DESeq
bat_genomeR. aegyptiacusGenome 226.88 276.54 272.25 237.0 273.45 250.64 178.8 265.64 274.84

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 332.84 377.43 301.0 0.18 -0.15 -0.33
7h 342.66 305.86 346.32 -0.16 0.02 0.18
23h 257.15 398.41 268.49 0.63 0.06 -0.57

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 332.84 342.66 257.15 0.04 -0.37 -0.41
Ebov 377.43 305.86 398.41 -0.3 0.08 0.38
Marv 301.0 346.32 268.49 0.2 -0.16 -0.37

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 48.05 61.43 55.51 0.35 0.21 -0.15
7h 71.8 61.23 59.66 -0.23 -0.27 -0.04
23h 64.52 54.89 77.97 -0.23 0.27 0.51

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 48.05 71.8 64.52 0.58 0.43 -0.15
Ebov 61.43 61.23 54.89 -0.0 -0.16 -0.16
Marv 55.51 59.66 77.97 0.1 0.49 0.39