TNFSF4

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
TNFSF4	GP34, CD252, OX4OL, TXGP1, CD134L, OX-40L,OX-40L, gp34, CD252	tumor necrosis factor (ligand) superfamily, member 4		pdf			NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus.

This gene is with low expression both in human cells and bat cells. But a slightly different expression level was found in human cells probes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	55	64	86	51	83	28	59	84	27
Read_Max	R. aegyptiacus	Transcriptome	12	19	11	13	13	17	9	15	14
Read_Max	R. aegyptiacus	Genome	42	31	32	25	30	27	18	54	36
DESeq	H. sapiens	Genome	711.35	789.36	1277.77	614.69	890.37	318.14	576.45	715.62	393.53
DESeq	R. aegyptiacus	Transcriptome	34.61	40.94	51.08	37.63	44.8	67.73	32.15	44.79	50.86
DESeq	R. aegyptiacus	Genome	608.45	685.43	840.18	556.94	599.36	1228.39	542.02	621.67	680.67

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	711.35	614.69	576.45	-0.21	-0.3	-0.09
7h	789.36	890.37	715.62	0.17	-0.14	-0.32
23h	1277.77	318.14	393.53	-2.01	-1.7	0.31

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	711.35	789.36	1277.77	0.15	0.84	0.69
Ebov	614.69	890.37	318.14	0.53	-0.95	-1.48
Marv	576.45	715.62	393.53	0.31	-0.55	-0.86

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	34.61	37.63	32.15	0.12	-0.11	-0.23
7h	40.94	44.8	44.79	0.13	0.13	-0.0
23h	51.08	67.73	50.86	0.41	-0.01	-0.41

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	34.61	40.94	51.08	0.24	0.56	0.32
Ebov	37.63	44.8	67.73	0.25	0.85	0.6
Marv	32.15	44.79	50.86	0.48	0.66	0.18

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material