TPP1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TPP1 CLN2, SCAR7, LPIC tripeptidyl peptidase I pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

The gene TPP1 is expressed throughout human cells and bat cells datasets, but without significant changes in expression profiles.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome71 135 103 86 131 179 111 174 121
Read_Max
batR. aegyptiacusTranscriptome 144 121 130 111 73 132 84 115 135
Read_Max
bat_genomeR. aegyptiacusGenome 148 124 107 114 71 80 76 143 157
DESeq
humanH. sapiensGenome 1156.84 1593.02 1414.78 1351.57 1320.42 2886.82 1417.69 1537.35 1786.42
DESeq
batR. aegyptiacusTranscriptome 1197.36 1254.52 1567.01 1143.75 1030.38 1211.04 946.55 1044.5 1212.47
DESeq
bat_genomeR. aegyptiacusGenome 1698.15 1764.22 2127.79 1867.33 1619.51 1942.45 1618.2 1509.77 1771.46

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1156.84 1351.57 1417.69 0.22 0.29 0.07
7h 1593.02 1320.42 1537.35 -0.27 -0.05 0.22
23h 1414.78 2886.82 1786.42 1.03 0.34 -0.69

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1156.84 1593.02 1414.78 0.46 0.29 -0.17
Ebov 1351.57 1320.42 2886.82 -0.03 1.09 1.13
Marv 1417.69 1537.35 1786.42 0.12 0.33 0.22

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1197.36 1143.75 946.55 -0.07 -0.34 -0.27
7h 1254.52 1030.38 1044.5 -0.28 -0.26 0.02
23h 1567.01 1211.04 1212.47 -0.37 -0.37 0.0

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1197.36 1254.52 1567.01 0.07 0.39 0.32
Ebov 1143.75 1030.38 1211.04 -0.15 0.08 0.23
Marv 946.55 1044.5 1212.47 0.14 0.36 0.22