TPP1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
TPP1	CLN2, SCAR7, LPIC	tripeptidyl peptidase I		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

The gene TPP1 is expressed throughout human cells and bat cells datasets, but without significant changes in expression profiles.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	71	135	103	86	131	179	111	174	121
Read_Max	R. aegyptiacus	Transcriptome	144	121	130	111	73	132	84	115	135
Read_Max	R. aegyptiacus	Genome	148	124	107	114	71	80	76	143	157
DESeq	H. sapiens	Genome	1156.84	1593.02	1414.78	1351.57	1320.42	2886.82	1417.69	1537.35	1786.42
DESeq	R. aegyptiacus	Transcriptome	1197.36	1254.52	1567.01	1143.75	1030.38	1211.04	946.55	1044.5	1212.47
DESeq	R. aegyptiacus	Genome	1698.15	1764.22	2127.79	1867.33	1619.51	1942.45	1618.2	1509.77	1771.46

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1156.84	1351.57	1417.69	0.22	0.29	0.07
7h	1593.02	1320.42	1537.35	-0.27	-0.05	0.22
23h	1414.78	2886.82	1786.42	1.03	0.34	-0.69

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1156.84	1593.02	1414.78	0.46	0.29	-0.17
Ebov	1351.57	1320.42	2886.82	-0.03	1.09	1.13
Marv	1417.69	1537.35	1786.42	0.12	0.33	0.22

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1197.36	1143.75	946.55	-0.07	-0.34	-0.27
7h	1254.52	1030.38	1044.5	-0.28	-0.26	0.02
23h	1567.01	1211.04	1212.47	-0.37	-0.37	0.0

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1197.36	1254.52	1567.01	0.07	0.39	0.32
Ebov	1143.75	1030.38	1211.04	-0.15	0.08	0.23
Marv	946.55	1044.5	1212.47	0.14	0.36	0.22

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material