ARRB2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ARRB2	ARB2, ARR2, BARR2,BARR2, DKFZp686L0365	arrestin, beta 2	NM_004313	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. T

he gene is 2 fold downregulated in human cells after 23 h or Marburg infection. The bat cells homolog is expressed without significant variation.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	57	51	26	55	52	55	66	82	30
Read_Max	R. aegyptiacus	Transcriptome	97	79	63	79	57	79	79	89	98
Read_Max	R. aegyptiacus	Genome	251	193	156	186	128	97	98	183	280
DESeq	H. sapiens	Genome	423.15	472.18	340.55	508.6	370.89	379.99	488.73	558.95	357.65
DESeq	R. aegyptiacus	Transcriptome	406.79	404.01	428.54	344.38	331.72	401.35	364.76	320.74	387.62
DESeq	R. aegyptiacus	Genome	2193.16	2148.46	2671.17	2386.75	2009.04	2036.44	1804.87	2361.39	2368.23

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	423.15	508.6	488.73	0.27	0.21	-0.06
7h	472.18	370.89	558.95	-0.35	0.24	0.59
23h	340.55	379.99	357.65	0.16	0.07	-0.09

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	423.15	472.18	340.55	0.16	-0.31	-0.47
Ebov	508.6	370.89	379.99	-0.46	-0.42	0.03
Marv	488.73	558.95	357.65	0.19	-0.45	-0.64

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	406.79	344.38	364.76	-0.24	-0.16	0.08
7h	404.01	331.72	320.74	-0.28	-0.33	-0.05
23h	428.54	401.35	387.62	-0.09	-0.14	-0.05

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	406.79	404.01	428.54	-0.01	0.08	0.09
Ebov	344.38	331.72	401.35	-0.05	0.22	0.27
Marv	364.76	320.74	387.62	-0.19	0.09	0.27

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material