ARRB2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ARRB2 ARB2, ARR2, BARR2,BARR2, DKFZp686L0365 arrestin, beta 2 NM_004313 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. T

he gene is 2 fold downregulated in human cells after 23 h or Marburg infection. The bat cells homolog is expressed without significant variation.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome57 51 26 55 52 55 66 82 30
Read_Max
batR. aegyptiacusTranscriptome 97 79 63 79 57 79 79 89 98
Read_Max
bat_genomeR. aegyptiacusGenome 251 193 156 186 128 97 98 183 280
DESeq
humanH. sapiensGenome 423.15 472.18 340.55 508.6 370.89 379.99 488.73 558.95 357.65
DESeq
batR. aegyptiacusTranscriptome 406.79 404.01 428.54 344.38 331.72 401.35 364.76 320.74 387.62
DESeq
bat_genomeR. aegyptiacusGenome 2193.16 2148.46 2671.17 2386.75 2009.04 2036.44 1804.87 2361.39 2368.23

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 423.15 508.6 488.73 0.27 0.21 -0.06
7h 472.18 370.89 558.95 -0.35 0.24 0.59
23h 340.55 379.99 357.65 0.16 0.07 -0.09

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 423.15 472.18 340.55 0.16 -0.31 -0.47
Ebov 508.6 370.89 379.99 -0.46 -0.42 0.03
Marv 488.73 558.95 357.65 0.19 -0.45 -0.64

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 406.79 344.38 364.76 -0.24 -0.16 0.08
7h 404.01 331.72 320.74 -0.28 -0.33 -0.05
23h 428.54 401.35 387.62 -0.09 -0.14 -0.05

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 406.79 404.01 428.54 -0.01 0.08 0.09
Ebov 344.38 331.72 401.35 -0.05 0.22 0.27
Marv 364.76 320.74 387.62 -0.19 0.09 0.27