BAIAP2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
BAIAP2	IRSP53,BAP2	BAI1-associated protein 2		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease.

The gene is downregulated in Marburg after 23 h, and upregulated in Ebola. There was no homolog identified in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	33	44	47	36	60	86	70	62	25
Read_Max	R. aegyptiacus	Transcriptome	30	21	22	24	14	21	13	36	26
Read_Max	R. aegyptiacus	Genome	27	22	19	19	13	13	11	44	28
DESeq	H. sapiens	Genome	492.16	483.4	452.74	515.45	421.3	868.19	523.81	529.37	359.82
DESeq	R. aegyptiacus	Transcriptome	161.47	152.58	211.1	142.01	117.08	134.45	104.45	196.81	165.45
DESeq	R. aegyptiacus	Genome	247.5	261.03	329.15	242.92	223.23	220.61	193.42	293.39	284.26

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	492.16	515.45	523.81	0.07	0.09	0.02
7h	483.4	421.3	529.37	-0.2	0.13	0.33
23h	452.74	868.19	359.82	0.94	-0.33	-1.27

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	492.16	483.4	452.74	-0.03	-0.12	-0.09
Ebov	515.45	421.3	868.19	-0.29	0.75	1.04
Marv	523.81	529.37	359.82	0.02	-0.54	-0.56

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	161.47	142.01	104.45	-0.19	-0.63	-0.44
7h	152.58	117.08	196.81	-0.38	0.37	0.75
23h	211.1	134.45	165.45	-0.65	-0.35	0.3

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	161.47	152.58	211.1	-0.08	0.39	0.47
Ebov	142.01	117.08	134.45	-0.28	-0.08	0.2
Marv	104.45	196.81	165.45	0.91	0.66	-0.25

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material