BAIAP2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
BAIAP2 IRSP53,BAP2 BAI1-associated protein 2 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease.

The gene is downregulated in Marburg after 23 h, and upregulated in Ebola. There was no homolog identified in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome33 44 47 36 60 86 70 62 25
Read_Max
batR. aegyptiacusTranscriptome 30 21 22 24 14 21 13 36 26
Read_Max
bat_genomeR. aegyptiacusGenome 27 22 19 19 13 13 11 44 28
DESeq
humanH. sapiensGenome 492.16 483.4 452.74 515.45 421.3 868.19 523.81 529.37 359.82
DESeq
batR. aegyptiacusTranscriptome 161.47 152.58 211.1 142.01 117.08 134.45 104.45 196.81 165.45
DESeq
bat_genomeR. aegyptiacusGenome 247.5 261.03 329.15 242.92 223.23 220.61 193.42 293.39 284.26

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 492.16 515.45 523.81 0.07 0.09 0.02
7h 483.4 421.3 529.37 -0.2 0.13 0.33
23h 452.74 868.19 359.82 0.94 -0.33 -1.27

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 492.16 483.4 452.74 -0.03 -0.12 -0.09
Ebov 515.45 421.3 868.19 -0.29 0.75 1.04
Marv 523.81 529.37 359.82 0.02 -0.54 -0.56

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 161.47 142.01 104.45 -0.19 -0.63 -0.44
7h 152.58 117.08 196.81 -0.38 0.37 0.75
23h 211.1 134.45 165.45 -0.65 -0.35 0.3

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 161.47 152.58 211.1 -0.08 0.39 0.47
Ebov 142.01 117.08 134.45 -0.28 -0.08 0.2
Marv 104.45 196.81 165.45 0.91 0.66 -0.25