PAK2
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| PAK2 | PAK65, PAKgamma | p21 protein (Cdc42/Rac)-activated kinase 2 | NM_002577 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
It is downregulated in human cells after 23 h of Ebola virus and Marburg virus infection. In bat cells it is downregulated in both mock probes.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 526 | 486 | 464 | 489 | 622 | 544 | 522 | 655 | 391 |
Read_Max |  | R. aegyptiacus | Transcriptome | 857 | 743 | 429 | 643 | 558 | 633 | 578 | 765 | 605 |
Read_Max |  | R. aegyptiacus | Genome | 972 | 683 | 369 | 713 | 480 | 375 | 479 | 942 | 644 |
DESeq | | H. sapiens | Genome | 8856.03 | 7087.08 | 7782.76 | 7924.18 | 8258.14 | 8926.9 | 7545.84 | 6897.8 | 7564.58 |
DESeq | | R. aegyptiacus | Transcriptome | 7390.88 | 6419.27 | 5078.93 | 6266.0 | 6161.98 | 6406.64 | 6969.11 | 6070.33 | 4972.84 |
DESeq | | R. aegyptiacus | Genome | 12234.28 | 10776.07 | 7954.38 | 10982.79 | 11035.22 | 12182.09 | 12595.88 | 10612.0 | 8756.27 |