PAK2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PAK2 PAK65, PAKgamma p21 protein (Cdc42/Rac)-activated kinase 2 NM_002577 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.

It is downregulated in human cells after 23 h of Ebola virus and Marburg virus infection. In bat cells it is downregulated in both mock probes.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome526 486 464 489 622 544 522 655 391
Read_Max
batR. aegyptiacusTranscriptome 857 743 429 643 558 633 578 765 605
Read_Max
bat_genomeR. aegyptiacusGenome 972 683 369 713 480 375 479 942 644
DESeq
humanH. sapiensGenome 8856.03 7087.08 7782.76 7924.18 8258.14 8926.9 7545.84 6897.8 7564.58
DESeq
batR. aegyptiacusTranscriptome 7390.88 6419.27 5078.93 6266.0 6161.98 6406.64 6969.11 6070.33 4972.84
DESeq
bat_genomeR. aegyptiacusGenome 12234.28 10776.07 7954.38 10982.79 11035.22 12182.09 12595.88 10612.0 8756.27

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8856.03 7924.18 7545.84 -0.16 -0.23 -0.07
7h 7087.08 8258.14 6897.8 0.22 -0.04 -0.26
23h 7782.76 8926.9 7564.58 0.2 -0.04 -0.24

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8856.03 7087.08 7782.76 -0.32 -0.19 0.14
Ebov 7924.18 8258.14 8926.9 0.06 0.17 0.11
Marv 7545.84 6897.8 7564.58 -0.13 0.0 0.13

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 7390.88 6266.0 6969.11 -0.24 -0.08 0.15
7h 6419.27 6161.98 6070.33 -0.06 -0.08 -0.02
23h 5078.93 6406.64 4972.84 0.34 -0.03 -0.37

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 7390.88 6419.27 5078.93 -0.2 -0.54 -0.34
Ebov 6266.0 6161.98 6406.64 -0.02 0.03 0.06
Marv 6969.11 6070.33 4972.84 -0.2 -0.49 -0.29