TAB2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TAB2 RP1-111D6.3, CHTD2, MAP3K7IP2, TAB-2,KIAA0733 TGF-beta activated kinase 1/MAP3K7 binding protein 2 pdf NONE

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Description

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors.

In human cells expression levels are stable in control samples, after Ebola infection the expression is up-regulated. In bat cells the expression patterns are complex. %%%%%%%%%%%%%%%%%%%%%

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome191 197 203 175 249 421 225 225 155
Read_Max
batR. aegyptiacusTranscriptome 542 410 241 300 297 412 302 353 332
Read_Max
bat_genomeR. aegyptiacusGenome 621 324 216 414 275 241 276 479 404
DESeq
humanH. sapiensGenome 3841.97 3328.85 3106.56 3655.75 3117.04 6846.43 3734.38 2964.99 3286.96
DESeq
batR. aegyptiacusTranscriptome 4944.39 4895.26 3216.08 4321.12 4190.81 4862.98 4759.87 4046.94 3494.59
DESeq
bat_genomeR. aegyptiacusGenome 6823.56 5934.28 4649.45 6946.95 6250.35 7413.42 7089.05 5958.2 5257.02

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3841.97 3655.75 3734.38 -0.07 -0.04 0.03
7h 3328.85 3117.04 2964.99 -0.09 -0.17 -0.07
23h 3106.56 6846.43 3286.96 1.14 0.08 -1.06

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3841.97 3328.85 3106.56 -0.21 -0.31 -0.1
Ebov 3655.75 3117.04 6846.43 -0.23 0.91 1.14
Marv 3734.38 2964.99 3286.96 -0.33 -0.18 0.15

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4944.39 4321.12 4759.87 -0.19 -0.05 0.14
7h 4895.26 4190.81 4046.94 -0.22 -0.27 -0.05
23h 3216.08 4862.98 3494.59 0.6 0.12 -0.48

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4944.39 4895.26 3216.08 -0.01 -0.62 -0.61
Ebov 4321.12 4190.81 4862.98 -0.04 0.17 0.21
Marv 4759.87 4046.94 3494.59 -0.23 -0.45 -0.21