TAB2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
TAB2	RP1-111D6.3, CHTD2, MAP3K7IP2, TAB-2,KIAA0733	TGF-beta activated kinase 1/MAP3K7 binding protein 2		pdf			NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors.

In human cells expression levels are stable in control samples, after Ebola infection the expression is up-regulated. In bat cells the expression patterns are complex. %%%%%%%%%%%%%%%%%%%%%

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	191	197	203	175	249	421	225	225	155
Read_Max	R. aegyptiacus	Transcriptome	542	410	241	300	297	412	302	353	332
Read_Max	R. aegyptiacus	Genome	621	324	216	414	275	241	276	479	404
DESeq	H. sapiens	Genome	3841.97	3328.85	3106.56	3655.75	3117.04	6846.43	3734.38	2964.99	3286.96
DESeq	R. aegyptiacus	Transcriptome	4944.39	4895.26	3216.08	4321.12	4190.81	4862.98	4759.87	4046.94	3494.59
DESeq	R. aegyptiacus	Genome	6823.56	5934.28	4649.45	6946.95	6250.35	7413.42	7089.05	5958.2	5257.02

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	3841.97	3655.75	3734.38	-0.07	-0.04	0.03
7h	3328.85	3117.04	2964.99	-0.09	-0.17	-0.07
23h	3106.56	6846.43	3286.96	1.14	0.08	-1.06

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	3841.97	3328.85	3106.56	-0.21	-0.31	-0.1
Ebov	3655.75	3117.04	6846.43	-0.23	0.91	1.14
Marv	3734.38	2964.99	3286.96	-0.33	-0.18	0.15

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	4944.39	4321.12	4759.87	-0.19	-0.05	0.14
7h	4895.26	4190.81	4046.94	-0.22	-0.27	-0.05
23h	3216.08	4862.98	3494.59	0.6	0.12	-0.48

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	4944.39	4895.26	3216.08	-0.01	-0.62	-0.61
Ebov	4321.12	4190.81	4862.98	-0.04	0.17	0.21
Marv	4759.87	4046.94	3494.59	-0.23	-0.45	-0.21

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material