XIAP
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| XIAP | API3, ILP1, MIHA, XLP2, BIRC4,hILP | X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase | NM_001167 |  |
 |
 |
 |
Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome.
This gene was found with 2 times up-regulation in Ebola after 7 h and 23 h and in Marbug after 23 h probes for human cells. However, no promising homolog was found in bat cells.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 178 | 127 | 266 | 115 | 250 | 536 | 169 | 134 | 322 |
Read_Max |  | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Read_Max |  | R. aegyptiacus | Genome | 434 | 333 | 216 | 282 | 227 | 188 | 277 | 419 | 354 |
DESeq | | H. sapiens | Genome | 2836.31 | 2154.97 | 2396.69 | 2217.35 | 2594.31 | 3921.13 | 2057.17 | 1923.44 | 5308.34 |
DESeq | | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
DESeq | | R. aegyptiacus | Genome | 4113.04 | 4492.24 | 3431.02 | 3531.24 | 4054.91 | 3725.64 | 4127.03 | 4201.82 | 3532.65 |