TNFRSF21

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
TNFRSF21	DR6, CD358, BM-018,DR6, CD358	tumor necrosis factor receptor superfamily, member 21	NM_014452	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors.

This gene was found to be well expressed in both human cells and bat cells probes, but without significantly different expression.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	342	335	215	331	399	346	477	619	423
Read_Max	R. aegyptiacus	Transcriptome	77	80	54	64	54	58	64	72	94
Read_Max	R. aegyptiacus	Genome	94	69	48	80	61	36	61	130	116
DESeq	H. sapiens	Genome	5175.4	4793.38	2881.18	5205.94	4329.15	4552.77	5780.9	6362.23	6426.13
DESeq	R. aegyptiacus	Transcriptome	778.13	713.54	639.86	632.81	682.15	616.93	788.58	609.92	817.98
DESeq	R. aegyptiacus	Genome	1164.47	977.49	975.19	1113.88	1132.88	1011.69	1289.84	1017.35	1287.71

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	5175.4	5205.94	5780.9	0.01	0.16	0.15
7h	4793.38	4329.15	6362.23	-0.15	0.41	0.56
23h	2881.18	4552.77	6426.13	0.66	1.16	0.5

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	5175.4	4793.38	2881.18	-0.11	-0.85	-0.73
Ebov	5205.94	4329.15	4552.77	-0.27	-0.19	0.07
Marv	5780.9	6362.23	6426.13	0.14	0.15	0.01

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	778.13	632.81	788.58	-0.3	0.02	0.32
7h	713.54	682.15	609.92	-0.06	-0.23	-0.16
23h	639.86	616.93	817.98	-0.05	0.35	0.41

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	778.13	713.54	639.86	-0.13	-0.28	-0.16
Ebov	632.81	682.15	616.93	0.11	-0.04	-0.14
Marv	788.58	609.92	817.98	-0.37	0.05	0.42

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material