AKT1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
AKT1 AKT, CWS6, PKBB, PKB-Beta, PRKBA, RAC, RAC-ALPHA,RAC, PKB, AKT v-akt murine thymoma viral oncogene homolog 1 NM_005163 pdf NONE

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Description

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome.

In human cells the gene expression levels are similar in all time points in absence and presence of Ebola. In bat cells the gene is downregulated after 7 h in both conditions, after 23 h the gene is upregulated in Ebola infected sample.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome175 168 133 141 160 146 211 194 116
Read_Max
batR. aegyptiacusTranscriptome 486 488 352 370 384 392 393 466 623
Read_Max
bat_genomeR. aegyptiacusGenome 539 393 298 489 327 234 336 568 682
DESeq
humanH. sapiensGenome 2113.79 1846.97 1564.7 1970.96 1531.79 1373.51 2037.87 1849.1 1512.41
DESeq
batR. aegyptiacusTranscriptome 3450.62 3862.31 3240.52 3013.55 3408.92 3405.28 3735.35 3005.09 4306.32
DESeq
bat_genomeR. aegyptiacusGenome 3818.27 3478.24 3632.97 4597.72 3918.75 4079.41 4297.96 3423.94 4768.99

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2113.79 1970.96 2037.87 -0.1 -0.05 0.05
7h 1846.97 1531.79 1849.1 -0.27 0.0 0.27
23h 1564.7 1373.51 1512.41 -0.19 -0.05 0.14

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2113.79 1846.97 1564.7 -0.19 -0.43 -0.24
Ebov 1970.96 1531.79 1373.51 -0.36 -0.52 -0.16
Marv 2037.87 1849.1 1512.41 -0.14 -0.43 -0.29

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3450.62 3013.55 3735.35 -0.2 0.11 0.31
7h 3862.31 3408.92 3005.09 -0.18 -0.36 -0.18
23h 3240.52 3405.28 4306.32 0.07 0.41 0.34

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3450.62 3862.31 3240.52 0.16 -0.09 -0.25
Ebov 3013.55 3408.92 3405.28 0.18 0.18 -0.0
Marv 3735.35 3005.09 4306.32 -0.31 0.21 0.52