Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

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AKT1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
AKT1	AKT, CWS6, PKBB, PKB-Beta, PRKBA, RAC, RAC-ALPHA,RAC, PKB, AKT	v-akt murine thymoma viral oncogene homolog 1	NM_005163	pdf			NONE

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Description

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome.

In human cells the gene expression levels are similar in all time points in absence and presence of Ebola. In bat cells the gene is downregulated after 7 h in both conditions, after 23 h the gene is upregulated in Ebola infected sample.

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