TNFRSF25

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TNFRSF25 DR3, TR3, DDR3, LARD, APO-3,DR3, TRAMP, WSL-1, LARD, WSL-LR, DDR3, TR3, APO-3 tumor necrosis factor receptor superfamily, member 25 NM_148965 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the TNF-receptorsuperfamily. This receptor is expressed preferentially in the tissuesenriched in lymphocytes, and it may play a role in regulating lymphocytehomeostasis. This receptor has been shown to stimulate NF-kappa B activityand regulate cell apoptosis. The signal transduction of this receptor ismediated by various death domain containing adaptor proteins. Knockoutstudies in mice suggested the role of this gene in the removal ofself-reactive T cells in the thymus. Multiple alternatively splicedtranscript variants of this gene encoding distinct isoforms have beenreported, most of which are potentially secreted molecules. The alternativesplicing of this gene in B and T cells encounters a programmed change uponT-cell activation, which predominantly produces full-length, membrane boundisoforms, and is thought to be involved in controlling lymphocyteproliferation induced by T-cell activation.

This gene was found to be with very low expression in human cells probes, no homolog was found in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome4 6 7 3 4 8 2 7 6
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 2 2 3 0 3 2 1 4 2
DESeq
humanH. sapiensGenome 32.46 40.78 67.52 21.53 23.76 47.06 17.67 43.37 52.11
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 6.88 6.39 18.97 0.0 7.81 3.92 2.25 10.31 8.56

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 32.46 21.53 17.67 -0.59 -0.88 -0.29
7h 40.78 23.76 43.37 -0.78 0.09 0.87
23h 67.52 47.06 52.11 -0.52 -0.37 0.15

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 32.46 40.78 67.52 0.33 1.06 0.73
Ebov 21.53 23.76 47.06 0.14 1.13 0.99
Marv 17.67 43.37 52.11 1.3 1.56 0.26

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA